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Mind Lab Pro® Ingredients

11 Research backed nootropics

 
Citicoline Cognizin

Citicoline as Cognizin®
250 mg

Cognizin
  • Brain Regeneration
    Brain Regeneration
  • Brain Circulation
    Brain Circulation
  • Brain Protection
    Brain Protection
  • Brain Energy
    Brain Energy
  • Brain Chemicals
    Brain Chemicals

Brain Bioactivities: Citicoline helps energize brain cells while optimizing the neural electrical impulses that power all thought. Citicoline also helps synthesize phosphatidylcholine (PC), the major phospholipid found in brain cell membranes. In combining brain energy + phospholipid synthesis, citicoline may be uniquely qualified for the intensive task of brain cell regeneration and repair. Citicoline also supports neurotransmitters, including acetylcholine, while supplying brain-protective antioxidant activity.

Potential Nootropic Benefits: Energizes and enhances mental performance without the crash of stimulants. Cognizin® Citicoline has been shown in human research to promote mood balance, memory, attention, focus and concentration. Long term, it may help maintain healthy brain function against age-related structural changes and mental decline. Citicoline has also been suggested to assist with recovery after brain injury.

  • MLP’s Cognizin® is a patented citicoline form with benefits for brain energy, mental performance & recall backed by multiple human clinical trials.
Citicoline Graph

Cognizin® Citicoline has been shown to boost brain cell membrane formation by 26% and brain energy by 13.6%.

Silveri MM, et al. Cognizin® Citicoline Increases Brain Energy (ATP) by 14% and Speeds up Formation of Brain Membranes by 26% in Healthy Adults. Soc. Neurosci, San Diego, CA

Phosphatidylserine

Phosphatidylserine (PS)

as Sharp PS® Green 100 mg

Sharp-PS® Green
  • Brain Regeneration
    Brain Regeneration
  • Brain Protection
    Brain Protection
  • Brain Energy
    Brain Energy
  • Brain Chemicals
    Brain Chemicals

Brain Bioactivities: PS is a phospholipid compound that comprises 15% of the brain’s fats. It is concentrated in brain cell membranes, where it helps maintain fluidity, optimizes receptors, and promotes neurotransmitters like acetylcholine and dopamine. It supports brain cell energy production by enhancing glucose metabolism. It may increase nerve growth factor (NGF) to support brain cell creation, maintenance and repair. PS also helps immune cells dispose of damaged, toxic brain cells, sparing neighboring brain cells from collateral damage.

Potential Nootropic Benefits: PS may sharpen memory, slow cognitive decline, and promote a positive-minded outlook. It has shown promise for helping elderly with brain degeneration, apparently slowing the progression of memory loss while helping with mood, anxiety, socialization and mental clarity. As a result, PS is the only nootropic with an FDA-qualified claim for reducing cognitive decline risk.

  • MLP’s Sharp PS® Green is a soy-free, non-GMO, eco-friendly phosphatidylserine derived from sunflower lecithin.
Phosphatidylserine (PS) Graph Phosphatidylserine (PS) Graph

Phospholipids like PS decline in the brain with age, along with most measures of cognitive performance.

Söderberg M, et al. J Neurochem. 1990 Feb;54(2):415-23l; http://ns.umich.edu/Releases/2001/Aug01/r081301a.html

Bacopa Monnieri

Bacopa monnieri, 150 mg

Standardized to 45% active bacosides

  • Brain Circulation
    Brain Circulation
  • Brain Protection
    Brain Protection
  • Brain Chemicals
    Brain Chemicals

Brain Bioactivities: Bacopa’s active bacosides are antioxidants that enhance other brain antioxidants, including superoxide dismutase (SOD) and glutathione peroxidase (GPx). This synergistic antioxidant activity helps protect brain cells from the age-accelerating effects of free radicals. Bacosides also promote acetylcholine, GABA & serotonin – all brain chemicals tied to focused thinking, clear memory and healthy mood. Animal research suggests bacosides may boost cerebral blood flow by 25%.

Potential Nootropic Benefits: Bacopa has strong ties to memory performance and a long association with new learning and retention. Human research shows Bacopa may slow the rate of forgetting newly acquired knowledge. Researchers have also suggested it may accelerate mental processing, optimize cognition under stress, and promote relaxation.

  • MLP’s 45% active bacosides is a clinically-tested standardization, supplying exact levels of Bacopa’s most active nootropic compounds.

Bacopa monnieri shows cognitive promise in human clinical trials.

Bacopa Form Study Subjects & Design Researchers’ Observations

Dried Bacopa plant extract (1.05 g/ day for 3 months)

School children (n=40) (age: 6-8 y), single blind trial

Significant improvement in maze learning, immediate memory, perception & reaction/performance times

Fresh whole Bacopa plant extract (100 mg / day for 3 months)

Children with ADHD (n=36) , Randomized, double blinded, placebo controlled

Significant improvement in learning and memory tasks

Bacopa monnieri dosed at 300 mg

Adults (n=76) (age:40-65 y) , single blind trial

Significant improvement in learning, task assessing attention, verbal and visual short-term memory and the retrieval of pre-experimental knowledge

Bacopa monnieri dosed at 300 mg

Adults, Double-blinded, placebo controlled

Improved early information processing, verbal learning and memory consolidation

Shinomol GK, et al. Recent Pat Endocr Metab Immune Drug Discov. 2011 Jan;5(1):33-49.
Lion's Mane Mushroom

Lion’s Mane Mushroom

Full Spectrum Extract with active hericenones and erinacines

500 mg

  • Brain Regeneration
    Brain Regeneration
  • Brain Protection
    Brain Protection

Brain Bioactivities: The only mushroom that supports brain health, Lion’s Mane supplies active nootropics called hericenones and erinacines. Animal research suggests Lion’s Mane stimulates Nerve Growth Factor (NGF) production, which accelerates neural regeneration and myelin nerve sheath synthesis. Optimized NGF may support brain plasticity for storage of new learning and memories, as well as promoting robust brain cell replication and healthy brain cell membrane function.

Potential Nootropic Benefits: A double-blind, placebo-controlled trial linked Lion’s Mane to significant cognitive improvements in adults aged 50-80 with mild cognitive impairment. Clinical trial researchers have also suggested that Lion’s Mane may help to maintain mood balance.

  • MLP’s full-spectrum Lion’s Mane Extract supplies all the mushroom’s active constituents, including brain-boosting hericenones & erinacines.
Lion's Mane Mushroom Graph

Lion’s Mane Mushroom (Yamabushitake) linked to significant cognitive improvements that declined after supplementation stopped.

Mori K, et al. Phytother Res. 2009 Mar;23(3):367-72.

Pterostilbene

Pterostilbene as Pterocarpus extract 90%

500 mcg

  • Brain Protection
    Brain Protection
  • Brain Circulation
    Brain Circulation

Brain Bioactivities: A high-bioavailability polyphenol found in grapes and blueberries, pterostilbene has soothing antioxidant properties that help maintain healthy brain function during the aging process. In vitro research shows cells exposed to pterostilbene exhibit increased expression of antioxidant enzymes including glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR). Pterostilbene’s unique brain-supportive activity optimizes cognition, modulates brain cell stress, and helps protect cerebral blood vessels.

Potential Nootropic Benefits: Pterostilbene is primarily valued as a neuroprotective nootropic for overall healthy brain function and healthy brain aging. Its performance-oriented nootropic activity is backed by early animal research only, but has been suggested to help with cognition and mood.

  • MLP uses premium, 90% pure pterostilbene extracted from botanicals only; many other forms on the market are made from synthetic materials.
N-Acetyl-L-Tyrosine

Tyrosine as
N-Acetyl-L-Tyrosine (NALT)
175 mg

  • Brain Protection
    Brain Protection
  • Brain Chemicals
    Brain Chemicals

Brain Bioactivities: Tyrosine is an amino acid compound used to synthesize catecholamine neurotransmitters involved in memory, mood and mental processing, including dopamine, epinephrine, and norepinephrine. Animal research suggests tyrosine may counter the impact of brain stress, restoring neurotransmitters that are depleted by stress to promote peak cognitive function.

Potential Nootropic Benefits: Human clinical research has suggested Tyrosine may help to promote working memory under multitasking conditions and optimize mental performance under high stress, fatigue and sleep deprivation. In addition to its reputation as a nootropic for maintaining mental performance under stress, Tyrosine has recently drawn interest as an attention &focus-oriented nootropic.

  • MLP’s N-Acetyl-L-Tyrosine is the best form for brain health: Easy to absorb and bioavailable, it delivers more nootropic activity than plain Tyrosine.
Tyrosine

Tyrosine was found to enhance mental performance with greater benefits recorded as tasks progressed from easier (1-BACK) to more difficult (2-BACK).

Colzato LS, et al. Front. Behav. Neurosci., 16 December 2013.

L-Theanine

L-Theanine as Suntheanine®

100mg

Suntheanine
  • Brain Waves
    Brain Waves
  • Brain Protection
    Brain Protection
  • Brain Chemicals
    Brain Chemicals

Brain Bioactivities: L-Theanine helps to increase activity of alpha brainwaves, which are associated with a state of wakeful relaxation and enhanced creativity. It seems to settle ”excitable” neurotransmitters while promoting ”calming” neurotransmitters like serotonin, dopamine and GABA. L-Theanine has been suggested by researchers to modulate the brain’s ”attention circuitry.” It may also protect neurons from damage, potentially helping to maintain clear thinking during the aging process.

Potential Nootropic Benefits: L-Theanine may instill a state of calm, relaxed tranquility while simultaneously sharpening attention, alertness and focus. It is used for studying, new learning, creative problem solving, art, or other tasks that require quiet contemplation. L-Theanine also helps to reduce the harsh jittery side effects of caffeine.

  • MLP’s premium Suntheanine® supplies 100% pure L-isomer-Theanine, shown in human clinical research to enhance Alpha brainwaves.

L-Theanine shows nootropic promise in numerous human clinical trials

L-Theanine Dose Subjects & Design Researchers’ Observations

L-Theanine 50 mg, L-Theanine 200 mg

8 Female university students) (age: 18-22 y), placebo-controlled, three-way crossover trial

Reported dose-dependent increase in alpha activity in occipital and parietal brain areas 30 min after consumption of L-theanine compared with placebo.

L-Theanine 200 mg

20 healthy males (age range 18–30 y), placebo controlled

L-theanine increased alpha brain wave activity in the occipital area, compared with placebo, among those with higher reported anxiety (p<0.05)

L-Theanine 50 mg

35 healthy young participants, randomized, placebo-controlled

Compared with placebo on EEG at 45, 60, 75, 90, and 105 min after ingestion, L-theanine 50 mg produced greater and increasing alpha activity (p<0.05)

L-Theanine 250 mg

15 participants (mean age 27.8 y), placebo-controlled

Attention-related alpha activity was greater and background alpha reduced for the L-theanine condition compared with placebo (significant attention modulation index, (p<0.05)

Bryan J. Nutr Rev. 2008 Feb;66(2):82-90.
Rhodiola rosea

Rhodiola rosea
Standardized to active nootropics: 3% rosavins, 1% salidrosides 50 mg

  • Brain Energy
    Brain Energy
  • Brain Chemicals
    Brain Chemicals
  • Brain Protection
    Brain Protection

Brain Bioactivities: Rhodiola is believed to stimulate and sustain cognition-critical neurotransmitters including norepinephrine, dopamine, and serotonin. It may further optimize these neurotransmitters by helping their transport across the blood-brain barrier. Rhodiola has acetylcholine-protective and antioxidant properties that may help with age-related decline. It has been suggested to increase the brain’s bioelectrical activity in small doses. Research suggests rhodiola’s nootropic effects begin within 30 minutes and last for up to six hours.

Potential Nootropic Benefits: As an ”adaptogen” herb, it helps strengthen mental + physical stress resistance while supporting brain energy, promoting clear, calm thinking under taxing conditions. Rhodiola is used to enhance mental processing, memory, learning, attention span, mood and work capacity. It also gained fame as a mind-body performance-enhancer among Eastern Bloc era Olympic biathletes and powerlifters.

  • MLP’s Rhodiola is standardized to supply 3% rosavins and 1% salidrosides, ensuring precise active nootropic levels in each capsule.
Rhodiola Rosea Graph

Rhodiola linked to dose-dependent mental energy benefits in human clinical research

Shevtsov VA, et al. Phytomedicine. 2003 Mar;10(2-3):95-105.

Vinpocetine

Vinpocetine 6 mg

  • Brain Protection
    Brain Protection
  • Brain Circulation
    Brain Circulation
  • Brain Chemicals
    Brain Chemicals
  • Brain Energy
    Brain Energy

Brain Bioactivities: Lab synthesized from periwinkle plant, vinpocetine enhances blood flow to the brain, which promotes glucose and oxygen utilization for brain energy metabolism. These activities may also help maintain neurons that might otherwise be lost to poor cerebral blood flow. Vinpocetine supplies antioxidant activity that further protects the brain from oxidative stress and toxins, while supporting brain chemicals serotonin, dopamine and norepinephrine.

Potential Nootropic Benefits: Vinpocetine has rapid uptake into the brain, and has been shown to promote attention, concentration, and memory in the short term (showing benefit to memory within 2 days). Its long-term brain supportive activity appears to help with age-related brain degeneration and age-related cognitive

Vitamin B6

Vitamin B6 as pyridoxal-5-phosphate (P-5-P) 2.5 mg

  • Brain Chemicals
    Brain Chemicals
  • Brain Circulation
    Brain Circulation
  • Brain Protection
    Brain Protection
  • Brain Regeneration
    Brain Regeneration

Brain Bioactivities: B6 optimizes neurotransmitters, helping synthesize serotonin, norepinephrine and GABA while supporting Tryptophan → serotonin, 5-HTP → serotonin, and DOPA → dopamine conversions.

B6 protects the blood-brain barrier’s microvascular system from the homocysteine that can damage blood vessel linings and contribute to cognitive decline. B6 also helps form myelin, the fatty sheath that surrounds and protects neurons.

Potential Nootropic Benefits: Mild B6 deficiency is common, and may deplete neurotransmitters to the point of cognitive concern. Supplemental B6 helps restore this critical nootropic for brain chemical production and conversion, and has been linked in research to mental performance, mood balance and a modest enhancement in the brain’s ability to store information.

  • MLP’s Pyridoxal-5-phosphate (P-5-P) is an advanced, metabolically active B6 form for brain health.
Vitamin B12

Vitamin B12

as Methylcobalamin 7.5 mcg

  • Brain Chemicals
    Brain Chemicals
  • Brain Circulation
    Brain Circulation
  • Brain Protection
    Brain Protection
  • Brain Energy
    Brain Energy

Brain Bioactivities: B12 is an important essential nutrient for the nervous system, including the brain, where it promotes the formation of healthy, protective nerve sheaths. B12 is a necessary nutritional player in peak brain energy metabolism and production of brain chemicals. Like B6, vitamin B12 is believed to help balance homocysteine levels, which may help protect the blood vessels that nourish the brain.

Potential Nootropic Benefits: Approximately 15% of adults over age 60 are deficient in B12. Low levels are tied to problems with mood and brainpower, typically in the context of age-related cognitive decline. B12, especially as methylcobalamin, helps restore levels needed for optimal cognitive function, bright mood and mental energy. As it protects nerve sheaths, B12 also supports healthy long-term brain function.

  • MLP’s Methylcobalamin B12 is better for brain health; its easy absorption and high bioavailability translate into greater nootropic activity.
Vitamin B12 Graph

Vitamin B12 may help regulate the homocysteine that is linked to age-related cognitive decline.

Seshadri S, et al. N Engl J Med 2002;346:476-83.

References