Fast and free shipping on orders over $180
Shopping Cart

Nootropics for Quitting Smoking — Managing Nicotine Addiction With Brain Supplements

By Dr. Ramon Velazquez Ph.D.

Quitting isn't easy.

But the right nootropics for quitting smoking can make the process not only easier, but also more successful.

Every year, millions of people across the globe decide once and for all that they will quit smoking.

But within the first year alone, at least half of these individuals find themselves picking up the habit like before. <1>

Studies have shown relapse rates approaching as high as 90% in certain regions — a daunting statistic that could make even the bravest soul give up on the idea of quitting altogether.

Yet quitting is always a possibility. A telltale sign is that the number of former smokers in the U.S. has already surpassed the number of current smokers.

The biggest hurdle seems to be choosing to quit and committing to the process. Once that step has been taken, there are countless measures available to help ease a person's transition back to a smoking-free lifestyle.

Many of these measures involve restoring brain health, which is precisely where nootropics for quitting smoking step in.

Nootropics and Smoking Cessation

Nootropics for quitting smoking can balance mood, strengthen willpower, ease withdrawal and more.
Since the release of the 1964 U.S. Surgeon General's Report, which confirmed that cigarette smoking has a negative effect on health, the prevalence of smoking has been on a consistent downswing.

Estimates by the U.S. National Institutes of Health (NIH) suggest that public health efforts have slashed the proportion of smokers in the population by half.

Nevertheless, smoking to this day remains the single most common preventable cause of death in the world. The Centers for Disease Control (CDC) has reported that smoking is responsible for just about one out of every five deaths in the U.S., which is more than the mortality rate of car accidents, firearm incidents, alcohol use, illegal drug use, and HIV combined.

Why does smoking continue to be so widespread?

  • There are a myriad of factors that account for this trend, but the issue could be boiled down to a simple single-word answer: addiction.

Quitting smoking is so darn tough because cigarettes and other tobacco products are loaded with the highly addictive chemical nicotine.

Within the first few seconds of inhalation, nicotine enters the bloodstream and starts affecting the entire body.

Once hooked, the body begins adjusting its physiology to the effects of nicotine to the extent that they very nearly become essential for normal functioning.

Fortunately, nootropics have the potential to help the body recover from this reliance on nicotine, starting with the brain.

There are at least 85 readily available nootropics that have proved capable of promoting brain health and mental performance.

Several of these nootropics may help with quitting by substituting the bioactivity of nicotine, albeit with less potency, while others may help more indirectly by diminishing the aftereffects of smoking cessation.

Before getting into which nootropics best fit the bill, it might first be useful to dig a bit deeper into the inner workings of nicotine addiction and exactly how nootropics could help.

Smoking markedly increases a person's risk of developing health complications throughout the body; quitting can cut this risk in half within the first few years, according to the CDC and NIH.

The Science Behind Smoking Addiction

Nicotine Pathway

Scientific research has repeatedly confirmed the addictive properties of nicotine, which is known to induce pleasure and reduce stress and anxiety. Nicotine achieves these effects during smoking by following a series of steps:

  1. Rapidly entering the bloodstream.
  2. Traveling to the lungs and brain.
  3. Binding to acetylcholine receptors.
  4. Allowing positive calcium ions to enter brain cells.
  5. Releasing neurotransmitters.

Exploiting Neurotransmitters

The nicotinic pathway alters the activity of a variety of neurotransmitters in the brain: <2>

  • Dopamine. Nicotine releases into the brain a surge of dopamine, the primary neurotransmitter in charge of the body's pleasure-reward system.
  • Glutamate. It also increases the release of glutamate, which subsequently triggers the release of gamma-aminobutyric acid (GABA). GABA, in turn, inhibits the natural release of dopamine.
  • Norepinephrine. In addition, nicotine also boosts levels of norepinephrine (as well as serotonin, acetylcholine, and endorphins) beyond the needs of the body.

Thus, nicotine supplies the body with excess amounts of dopamine and other neurotransmitters while gradually making it more difficult for the body to release these neurotransmitters on its own.

Additional Stimulatory Effects

Beyond nicotine, cigarette smoke often contains other compounds that contribute to addiction.

  • Lighting a cigarette and burning otherwise harmless additives such as glycerol and sorbitol triggers the release of acetaldehyde, which not only is toxic but also blocks enzymes required for the body to produce more dopamine.
Tobacco Additives. Whereas nicotine makes smoking addictive, the additives found in tobacco smoke bring about the greatest harm.
  • Tobacco smoke contains well over 7,000 chemicals, hundreds of which — including hydrogen cyanide, ammonia, and carbon monoxide — are known to have deleterious effects on the body, according to the U.S. National Cancer Institute.


How Nootropics Can Help You Quit

Among the many positive ways in which nootropics can affect the brain include facilitating the release of neurotransmitters. Nootropics can help the body gradually restore its natural ability to stimulate certain neurotransmitters, counteracting one of the main consequences of nicotine addiction.

Supporting Biopathways

Whereas synthetic compounds and drugs such as nicotine are capable of suddenly boosting the supply of available neurotransmitters, natural nootropics maximize the body's inherent ability to provide neurotransmitters.

  • In other words, nicotine offers a surge of "good feeling" but leaves the body helpless over time. In contrast, nootropics help the body get better at making itself "feel good."

What's more, nicotine provides a potentially harmful short-term fix, while nootropic supplementation steadily and safely leads to long-term benefits. By supporting fundamental biopathways, nootropics protect the body against addiction.

Rebuilding Neurotransmitter Activation

Once nicotine addiction sets in, nootropics are faced with the challenge of recovering the body's diminished capacity to release important neurotransmitters.

Nonetheless, nootropics may be able to bolster the natural release of dopamine, noradrenaline, serotonin, and other compounds inhibited by nicotine use. In effect, nootropics serve to replace nicotine's knack for releasing neurotransmitters gradually but without such harmful side effects. <3>

It is important to note that no single nootropic exactly mirrors the bioactivity of nicotine. As such, recovering neurotransmitter activation may require the effort of a nootropic stack.

Combating Tolerance

Desensitization to nicotine is common among habitual smokers, wherein they require increasingly greater doses of nicotine to feel the same level of satisfaction.

Serious cases of addiction involving high tolerance may call for elevated doses of nootropics to cover an individual's basic needs. Though not generally recommended, this could prove more effective when conducted safely and appropriately.

Managing Withdrawal is Key

As useful as nootropics may be at countering the physiological effects of nicotine, this process usually takes a considerable amount of time.

However, nootropics have the potential to help the body deal with arguably the most taxing part of quitting smoking — i.e., withdrawal — as these long-term changes take place. The harsh symptoms of withdrawal, ranging from depression and anxiety to lapses in memory and judgement, make it so much harder to stop smoking than to let go of other habits.

Easing Withdrawal Symptoms

Nootropics have demonstrated that they can help reduce the severity of most symptoms of nicotine withdrawal, including the following:

Collectively, these potential benefits are centered around reducing the body's dependance on nicotine by making life less painful without it. Decreasing dependance may further minimize day-to-day nicotine cravings.

How to Approach Quitting

There are various ways to go about the business of quitting smoking, with the most popular strategies involving nicotine substitution. This type of replacement therapy allows individuals to have their nicotine fix in the form of a patch, a spray, or gum, drastically reducing a person's exposure to cigarette toxins.

However, nicotine replacement therapy has similar side effects as smoking because all of the sources still contain nicotine. Though the method may draw people away from smoking, it does little to address the overarching issue of nicotine addiction.

  • On the other hand, nootropics aim to get to the root of addiction by steering clear of nicotine all together

Replacement therapy may make quitting easier to cope with temporarily, but nootropics are healthier and have the potential to make quitting a reality farther down the line.

So whether you decide to gradually wean off from smoking or go cold turkey, nootropics can improve your chances of achieving your goal.

Mind Lab Pro® Nootropics for Quitting Smoking

Rhodiola Rosea

Mind Lab Pro's Rhodiola Rosea is the optimal nootropic for quitting smoking. The herbal adaptogen contains bioactive ingredients that can support the release of the three primary neurotransmitters affected by nicotine addiction: dopamine, norepinephrine, and serotonin. Rhodiola may also help to protect and sustain acetylcholine levels.

Furthermore, multiple preclinical trials have confirmed that Rhodiola can reduce various withdrawal symptoms. In one study, researchers observed that Rhodiola reduced tangible signs of nicotine withdrawal — notably, anxious behaviors such as shaking, tremors, and hair raising. <4> A separate group discovered that Rhodiola helped recover serotonin levels during a period of withdrawal. <5>

A bonus to supplementing with Rhodiola is that it may help mitigate the weight gain that often arises as a secondary effect of quitting. The nootropic is capable of reducing levels of cortisol (a stress hormone that can increase belly fat) as well as stimulating fat metabolism for overall fat reduction.

More on Mind Lab Pro® Rhodiola Rosea


L-Theanine is a soothing amino acid present within green tea. When consumed, the nootropic increases the activity of alpha brain waves to promote wakeful relaxation, enhance mood, and calm the mind. 

Although L-Theanine is most popularly used to wash away performance anxiety and jitters while sustaining mental focus, it may similarly serve to soften many of the side effects of withdrawal.

A recent study suggested that the supplement could help deal with withdrawal symptoms by repairing the motivation-reward pathway. "L-Theanine reduced the nicotine-induced reward effects via inhibition of the nAChR-dopamine reward pathway," the researchers concluded. <6>

More on Mind Lab Pro® L-Theanine

N-Acetyl L-Tyrosine

N-Acetyl L-Tyrosine is a stress-reducing amino acid that serves as a precursor in the synthesis of several neurotransmitters.

Although no clinical studies have directly verified its effect on quitting, its role in replenishing neurotransmitters make it a strong candidate for the job. For example, the nootropic is a precursor to dopamine and norepinephrine. 

High stress is known to deplete the body's reserve of catecholamines like norepinephrine.

N-Acetyl L-Tyrosine is capable of maintaining sufficient norepinephrine levels during times of stress by suppressing the production of stress hormones. 

More on Mind Lab Pro® N-Acetyl L-Tyrosine

What about synthetic nootropics? 

Proponents of synthetic nootropics such as oxiracetam and piracetam have claimed that they may also help fight withdrawal symptoms.


But the use of synthetic nootropics is complicated by differences in legal stances across the world. Oxiracetam, for instance, is not regulated, and thus legal, in the U.S., Canada, and the U.K.

On the other hand, Piracetam, is not legal in the U.K.


Mind Lab Pro® nootropics for quitting smoking reinvigorate neurotransmitter activity and help the body cope with withdrawal. 

However you frame it, smoking is a tough habit to break. A premium natural brain-boosting stack like Mind Lab Pro® can work wonders — reducing the toll on your body as it fights against nicotine addiction. Rather than offer a makeshift patch to cover up a chronic complaint, Mind Lab Pro® nootropics are designed to help you quit smoking while also improving your long-term health.

These statements have not been approved by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

This article is an opinion and explanation of current research given by the author. It is not an expression of a medical diagnosis or treatment and should not be relied on as such.

The world's smartest brain supplement.

The world's smartest

Get limitless brainpower insights. Direct to your inbox.

Plus offers, discounts & early
access to sales.

Mind Lab Pro® - Facebook Icon Mind Lab Pro® - Instagram Icon Performance Lab® - LinkedIn Icon

© 2015 - 2024 Performance Lab USA Corp.
All Rights Reserved.
941 West Morse Boulevard, ste 100, Winter Park, 32789, United States

B Corp Certified

The statements on this page have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent disease.