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Rhodiola Rosea

By Dr. Ramon Velazquez Ph.D.

Mind Lab Pro® supplies:
Rhodiola Rosea 50 mg
standardized to 3% rosavins and 1% salidrosides

Rhodiola rosea is an herbal adaptogen that may strengthen mental and physical stress resistance  helping to promote mental energy and clear, calm thinking under challenging conditions.*

Brain Support

  • Modulates stress hormones that may diminish cognitive function.*
  • Optimizes brain chemicals norepinephrine, dopamine and serotonin.*
  • May help to protect and sustain brain chemical acetylcholine.*
  • Suggested to supply multiple neuroprotective bioactivities.*

Nootropic Effects

  • Fights mental fatigue; supports an active, stimulated brain-state.*
  • Promotes peak mental performance during times of stress.*
  • Optimizes physical and mental work capacity.*
  • Supports a calm and balanced emotional state.*
  • May produce stimulating effects in 30 minutes that last 4-6 hours.1*

Mind Lab Pro®'s Rhodiola Rosea

  • Rhodiola Rosea, superior to the Rhodiola crenulada in other stacks.
  • Standardized for a minimum of 3% rosavins and 1% salidrosides.
  • Strongest potency of Rhodiola rosea nootropic bioactives available.
  • Enhanced-potency form of a traditional herbal performance booster.
  • 50 mg; smaller Rhodiola dosages are suggested to be more stimulating than larger doses.

Why Mind Lab Pro® Includes Rhodiola Rosea

Every day we are bombarded with physical, emotional and chemical stressors that can knock the endocrine system off-balance  which may in turn lead to stress-related mental fatigue and brain fog.2

Rhodiola rosea may help because it is an adaptogen: Part of a class of herbs that are used to strengthen mind-body resistance to stress to maintain normal, balanced physiological function.

As an adaptogen, Rhodiola supplies short-term performance support and long-range brain health support by acting on two separate pathways:3

  1. A single dose of Rhodiola affects The sympatho-adrenal-system (SAS), which controls the body’s reaction and adaptation to short-term stressors like emergency “fight-or-flight” situations.
  2. Ongoing adaptogen supplementation is believed to regulate the hypothalamic–pituitary–adrenal axis (HPA axis): A stress-response center in the body that manages long-term stress.

By countering stress's brain-dulling effects, Rhodiola rosea helps energize the brain for sharp cognitive function when it counts the most.

In Russia, Rhodiola has been traditionally used by workers to improve productivity; by cosmonauts to stay mentally sharp under pressure; and by world-class athletes to gain a safe, legal competitive edge.

  • Mind Lab Pro® includes Rhodiola Rosea as a cognition-enhancing psychostimulant that works best during mental stress like athletic competition, sleep deprivation, test-taking, presentations and deadlines.

Beyond its performance-enhancing effects, Rhodiola rosea optimizes several biological pathways for all-around brain health support and diverse cognitive enhancements. In reviews and research studies, it has been suggested to:

  • Enhance both mental and physical performance and work capacity without the negative effects or crashes of typical stimulants.4
  • Reduce general fatigue under stressful conditions.5
  • Help to promote a calm, positive-minded mood.6

How Rhodiola Rosea may support mental performance and brain health

Brain Chemicals

Rhodiola Rosea may sustain brain chemicals including norepinephrine, serotonin and dopamine.  Neurotransmitters in this class are critical for cognitive processing speed, concentration, mood and memory. Rhodiola may modulate the monoamine oxidase enzymes that would otherwise destroy these neurotransmitters.7

Rhodiola has also been suggested to help maintain the brain chemical acetylcholine by inhibiting ACHe, an enzyme that degrades acetcylcholine.8

Brain Energy

Small doses of Rhodiola Rosea have been suggested to raise the brain’s electrical activity.9 Some researchers have suggested that Rhodiola's stimulating effects may commence within 30 minutes of taking the herb, and may continue for up to 6 hours.1 The herb’s stress-resistance benefits and stimulating benefits combine to promote energized mental clarity.

Brain Protection

Rhodiola rosea has been suggested to exert antioxidant, inflammation-modulating, and  structure-supportive effects on the brain that may help with some aspects of age-related cognitive decline.10

Rhodiola's neuroprotective ability extends to influence the endocrine system’s HPA axis, helping to strengthen mental (and physical) resistance to stress.11

Mind Lab Pro® Stack Strategy: Rhodiola Rosea + Citicoline for Crash-Free Mental Energy

Among the adaptogens, Rhodiola rosea may be most known for its potential to ease fatigue in stressful situations while promoting revitalizing mental energy  effects it achieves by optimizing stress hormones and cognitive neurotransmitters.

Citicoline is another mental energy nootropic, but it works differently from Rhodiola; instead enhancing brain energy metabolism by optimizing brain cells' mitochondria powerhouses.

  • Together in Mind Lab Pro®, Rhodiola rosea and Citicoline combine to promote mental energy in separate, complementary ways. Both Rhodiola and Citicoline have been noted to achieve their brain-energizing effects without the crash or side effects of caffeine or other typical energizers. More on Mind Lab Pro®'s Citicoline

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


  1. Panossian A, Wagner H. Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration.Phytother Res.2005;19(10):819–38.
  2. Bose, M., Oliván, B., & Laferrère, B. (2009). Stress and obesity: the role of the hypothalamic–pituitary–adrenal axis in metabolic disease. Current Opinion in Endocrinology, Diabetes, and Obesity, 16(5), 340–346.
  3. Panossian A, Wikman G. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity. Pharmaceuticals (Basel). 2010 Jan; 3(1): 188–224.
  4. Hung SK, Perry R, Ernst E. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine. 2011 Feb 15;18(4):235-44. doi: 10.1016/j.phymed.2010.08.014. Epub 2010 Oct 30.
  5. Darbinyan V, Kteyan A, Panossian A, et al. Rhodiola rosea in stress induced fatigue – a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine 2000;7:365-371.
  6. Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malstrom C, Panossian A. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depressionNord J Psychiatry. 2007; 61(5):343-348.
  7. van Diermen D et al. Monoamine oxidase inhibition by Rhodiola Rosea L. roots. J Ethnopharmacol. 2009 Mar 18;122(2):397-401.
  8. Hillhouse B, et al. Acetylcholine Esterase Inhibitors in Rhodiola rosea. Pharmaceutical Biology, Volume 42, 2004 - Issue 1.
  9. Brown R, et al. Rhodiola Rosea: A Phytomedicinal Overview. HerbalGram. 2002; 56:40-52 American Botanical Council
  10. Zhang J, et al. Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus. Behav Brain Res. 2013 May 1;244:70-81.
  11. Schriner SE, et al. Protection of human cultured cells against oxidative stress by Rhodiola Rosea without activation of antioxidant defenses. Free Radic Biol Med. 2009;47:577-584

These statements have not been approved by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

This article is an opinion and explanation of current research given by the author. It is not an expression of a medical diagnosis or treatment and should not be relied on as such.

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The statements on this page have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent disease.