Best Supplements for Anxiety in 2025

Feeling anxious? A class of brain-healthy nutrients called nootropics may help to relieve anxiety symptoms in many ways. And carefully combining nootropics into "stack" dietary supplements can expand the benefits, for more comprehensive support for all types of anxiety disorders.

In this article, we'll start by discussing what anxiety is, what nootropics are, and how they relate to each other. We'll then go into the individual nootropic ingredients that have shown promise for easing anxiety in clinical research. Finally, we will conclude with several supplements on the market today that include the best nootropics for anxiety.

The best part? All of our supplement recommendations can be seamlessly combined to form the ultimate anti-anxiety stack. Ready to chillax? Let's get to it!

Key Takeaways

• Supplements for anxiety may work by targeting brain chemistry, stress regulation, and brain wave activity to promote a calm yet alert state, which can help reduce feelings of apprehension.
• L-Theanine is one of the most effective nootropics for anxiety, known for its calming effects while improving attention and cognitive performance.
• Bacopa Monnieri has shown promise as one of the adaptogen herbal supplements, reducing anxiety and supporting mood by modulating the stress response and reducing cortisol levels.
• Choline (as Citicoline) plays a critical role in brain health and has been linked to reduced anxiety, thanks to its influence on acetylcholine, a neurotransmitter involved in regulating anxiety.
• Phosphatidylserine (PS) helps reduce anxiety symptoms by lowering cortisol production and supporting cognitive functions under stress.
• Lion's Mane Mushroom is gaining popularity as an anxiolytic nootropic, showing potential for reducing anxiety and depression while supporting nerve growth factor (NGF) production.
• Rhodiola Rosea is another powerful adaptogen that helps balance physical and psychological stress responses, providing support for anxiety, especially in high-pressure situations including performance anxiety.
• Probiotics and Prebiotics contribute to brain health through the gut-brain axis, enhancing mood regulation and supporting overall mental wellness.

**Note: Anxiety is a serious medical concern. Only a doctor can diagnose issues like anxiety and panic disorder. Further, only a doctor can design the best possible plan for treating anxiety, whether it's with antidepressant medications, natural supplements, lifestyle changes or something else. Be sure to consult with your doctor before considering any of the supplements discussed in this article.

Best Supplements for Anxiety in 2025

Top Anti-Anxiety Nootropic Stack: Mind Lab Pro®

Mind Lab Pro® (MLP®, the Universal Nootropic) supplies 11 natural nootropics, including many of the best nootropics for anxiety, specifically.

It includes natural support for social anxiety, performance anxiety, reducing stress, balancing mood and more. But that's just one part of what this formula can do.

MLP® is designed to improve cognitive functioning in assorted ways. By optimizing the entire brain, it is uniquely able to improve cognitive function in many ways, helping with:

• Focus, attention & concentration
• Memory, recall and learning
• Mental energy (without caffeine)
• Motivation, intensity and drive
• Creative, clear and relaxed thinking
• Mood improvement

In other words, Mind Lab Pro is designed to help you perform better at everything. Work, studying, athletics, gaming, creating, socializing or any other activity where you want to excel.

Whether you're feeling anxious or not, this formula can optimize your brain's health and performance.

Additional top nootropic supplement picks to consider for anxiety

Mind Lab Pro® is the top nootropic for anxiety. But there are several other high quality formulations that can help with anxiety too. They include:

Performance Lab® Prebiotic: Boosts the gut-brain connection, nourishing probiotics in the digestive tract (the microbiome) which can have a big impact on mood and mental wellness.

Performance Lab® Omega-3: Omega-3s benefit mood; this supplement supplies them in a vegan algae-sourced form that is cleaner and more eco-friendly than fish oil -- but equally effective.

Performance Lab® Sleep: Natural sleep formula with soothing brain chemical and muscle relaxation support to ease anxiety and enable a deep, restful night's sleep.

We go into more detail on each of these nootropic supplements further down the page.

What is Anxiety?

Anxiety is a general feeling of unease, worry, or fear that can range from being mild to severe. It is a main symptom of panic attacks, PTSD, social anxiety, phobias and other mental health challenges.

Anxiety can be triggered by certain events or situations, such as exams, job interviews, financial stress, or medical reasons.

Generalized Anxiety Disorder (GAD) is a health problem where this excessive worry is near-constant, often without a specific trigger. It's also worth noting that anxiety is often accompanied by depression, too. as well as physical symptoms, including possible high blood pressure concerns. More chronic or severe cases of anxiety and stress (as well as severe depression and major depressive disorder) must be addressed by a health professional.

Mild occasional anxiety, however, may be manageable via self-help and lifestyle changes.

Brain-boosting nootropics for anxiety may be part of an overall lifestyle regimen designed to ease your anxiety symptoms, improve your stress response and support your mental health.

What are Nootropics?

Nootropics are also known as smart drugs, brain boosters, brain supplements and cognitive enhancers. Nootropic supplements may improve cognitive performance in many ways: Processing, alertness, mental energy, memory, recall, attention, focus and more. The best nootropics are also safe and healthy for the brain.

A nootropic can be a single nutrient. "Nootropic" can also refer to a supplement that combines several brain-boosters into one formula. A "Nootropic Stack" can refer to one product with several ingredients, or several products that are combined into an overarching supplement regimen.

In this article, we are covering the best nootropics for anxiety by detailing both individual nootropic ingredients and multi-nootropic stacks.

How Nootropics May Help Anxiety

So, what roles do nootropics for anxiety perform? Many nootropics can help promote a more relaxed, calm, yet alert mindset.

Some of the main mechanisms of action these nutrients may offer to assist those with anxiety disorder include:

• Anti-stress effects: Stress and anxiety go hand-in-hand. Some nootropics help strengthen the body's natural resistance to stress, including regulating stress hormones like cortisol.
• Brain chemical balance: Some nootropics directly influence the neurotransmitter systems (brain chemicals), especially the catecholamine brain chemicals that regulate anxiety.
• Brain wave support: One nootropic for anxiety, L-Theanine, helps "tune" the brain to frequencies associated with calm relaxation. More on that in a minute.
• General mood support: Nootropics can help with depression symptoms, instead promoting a bright and balanced mood that is more resilient when it comes to staving off anxiety symptoms.

Next, let's dig into some of the individual nootropic ingredients that help to deliver these benefits and may be combined into effective anti-anxiety stacks.

The Best Anti-Anxiety Nootropic Ingredients

There are dozens of nootropic compounds that play a role in regulating mood.

Following are some of the best to look for in nootropic supplements due to their research-backed benefits for mood (including anxiety), safety, and extensive history of use.

The top nootropic compounds for anxiety include:

L-Theanine

A natural amino acid found in tea leaves, particularly in green and black tea, L-Theanine may be the single best nootropic for anxiety relief.

L-theanine is the active substance in green tea thought to support a broad spectrum of effects that are all tied to relaxation and mood enhancement. It can support a state of calm, relaxed tranquility while simultaneously reducing anxiety and sharpening attention, alertness, and concentration.

In short, L-Theanine promotes relaxation and may help regulate anxiety levels. It works by crossing the blood brain barrier, where it helps:

• Increase the production of certain neurotransmitters in the brain, including dopamine and serotonin, which can have a soothing and mood-enhancing effect
• Raise activity of Alpha brain waves. The alpha frequency (8-14 Hz) settles the central nervous system and is associated with feelings of calm alertness, or wakeful relaxation.

L-Theanine may support cognitive function in many additional ways, including helping with attention, multitasking, cognitive performance under stress and overall brain health.

It is also a well-known nootropic to minimize the jitters and nervousness associated with caffeine use.

In a human clinical trial, researchers reported that L-Theanine intake appeared to have a calming effect on stressed study subjects.

The researchers noted L-Theanine appeared to soothe an over-activated sympathetic nervous system, as measured by slower heart rate and lower levels of stress markers in saliva, as well as settling "excitable" neurons in the brain.(1)

Learn more about L-Theanine

Bacopa Monnieri

Bacopa monnieri, known as Brahmi in traditional Ayurvedic health practices, is a natural nootropic herb renowned for its cognitive-enhancing properties. It is believed to promote mental clarity, memory, and overall brain function.

Bacopa is also considered an adaptogen herb that strengthens mind-body resistance to stress and helps maintain physiological balance.

As a stress-busting adaptogen, Bacopa also offers a lot of promise for relieving anxiety -- further helping students, as well as athletes, driven professionals, or anyone seeking to maintain sharp performance through feelings of apprehension.

Researchers have noted:

• A single dose of Bacopa extract improved cognitive performance, enhanced mood, and blunted release of the stress hormone cortisol(2)
• In a smaller study, Bacopa showed a trend for decreased levels of anxiety(3)
• In a 2023 review, Bacopa demonstrated anxiety-reducing effects and was named a "calming cognitive enhancer."(4)

With this research and long history of use in mind, you can see how Bacopa may have positive long-term benefits for anxiety (and overall brain health) without side effects or risks.

Learn more about Bacopa Monnieri

Choline (as Citicoline)

Choline is a vital nutrient that plays a fundamental role in brain function and cognitive health. It serves as a precursor to acetylcholine, a neurotransmitter that regulates anxiety and is crucial for memory, learning, and muscle control.

Getting enough choline intake supports the formation and maintenance of healthy neural membranes, which enhances signal transmission between brain cells.

Choline has been studied for its potential to ease anxiety. In one large study, researchers reported that that higher blood levels of choline were associated with lower levels of anxiety.(5)

Tip: Citicoline is the best form of choline to take. When ingested, citicoline breaks down to release choline and another nootropic called uridine. It's like a 2-in-1 mini stack for anxiety and much more.

Learn more about Citicoline

Phosphatidylserine (PS)

Phosphatidylserine (PS) is a phospholipid nootropic used in brain cell genesis, repair and maintenance. It also shows a positive effect on neural energy metabolism, neurotransmitters, nerve growth factor (NGF) and other brain pathways.

PS is the leading nootropic for memory and delivers many other brain benefits too, helping with competitive cognitive performance, language and more. But what about anxiety?

PS may help reduce symptoms of anxiety by counteracting the effects of stress on the body.

It has been shown to potentially slow the production of cortisol. Cortisol is the stress hormone that can be produced in excess in response to chronic stress, which can wreak havoc on the body when uncontrolled. Cortisol is also linked to anxiety symptoms.

In one study, researchers reported that taking PS daily for 30 days was associated with feeling less stressed and having a better mood.(6)

Given its far-reaching benefits for brain health and cognitive function, PS is a great nootropic choice for any anti-anxiety stack.

Learn more about Phosphatidylserine (PS)

Lion's Mane Mushroom

Lion's Mane Mushroom has emerged as a prominent brain supplement in recent times. Researchers propose that Lion's Mane Mushroom's support of NGF may yield several brain-related benefits, including potential support for people with anxiety concerns.

In one study, 30 women took either a placebo or lion's mane mushroom-infused cookie for four weeks and were then tested for various mental wellness parameters.

After the data was analyzed, researchers reported that lion's mane mushroom has the potential to reduce depression and anxiety.

Researchers further noted that the anxiolytic benefits appeared to be from a different unknown mechanism of action from the mushroom's well-known NGF-enhancing effects.(7)

Lion's mane is now a highly sought-after nootropic compound in top-shelf brain supplements -- for its potential in anxiety relief, depression symptoms and more.

Learn more about Lion's Mane Mushroom

Rhodiola Rosea

Rhodiola Rosea is a nootropic herb that has long been prized in traditional Russian herbalism for its gold-colored root.

Like Bacopa, Rhodiola is considered an herbal adaptogen: It improves the body's stress response, helping to promote more balanced physiological reactions to various mental and physical stressors.

In traditional use, Rhodiola is taken as a legal performance enhancer -- helping to promote clean natural energy, reduce stress, boost physical performance and improve cognitive function.

As for its potential in helping to relieve anxiety, Rhodiola has demonstrated benefits in clinical research. It has been shown to:

• Help promote a bright mood in study subjects experiencing mild-to-moderate depression.(8) Depression is often associated with anxiety, including social anxiety.
• In a pilot study, researchers found that subjects with General Anxiety Disorder (GAD) who took Rhodiola rosea experienced significant improvements in their anxiety symptoms.(9)

Rhodiola rosea is a powerful nootropic that's perfect for helping to fight the many negative effects of stress. It seems well suited for all types of anxiety, especially performance anxiety.

Learn more about Rhodiola Rosea

Probiotics and Prebiotics

The microbiome, comprised of beneficial bacteria in the gut, is closely tied to brain function (especially mood) and is sometimes regarded as the "second brain."

Taking probiotics can help the microbiome, but the consumption of prebiotics may offer even greater advantages.

Prebiotic fiber nourishes your microbiome, helping probiotics to grow and thrive. A thriving microbiome, in turn, exerts a multi-faceted impact on health, helping digestion, immune function, energy and more -- including playing a pivotal role in the synthesis of brain chemicals.

Remarkably, the gut contributes to the production of approximately 95% of the body's serotonin, often dubbed the "feel-good" brain chemical.(10)

In a published review, researchers reported that probiotics could help relieve depressive symptoms in subjects with anxiety disorders and may be used as an adjunct therapy for mood problems.(11)

Did you know? The Bifidobacterium strain of probiotics optimizes several brain chemicals, including dopamine, GABA, and norepinephrine, potentially imparting mood-regulating and anti-stress benefits.

Omega-3s and Fish Oil for Anxiety

Omega-3 fatty acids are renowned for their role in promoting well-being across various bodily systems, benefiting the central nervous system, cardiovascular system, and immune system. They also enhance cognitive functions and brain health -- including some aspects of mood.

Researchers have reported that a number of clinical trials suggest that Omega-3 fatty acids may help to reduce anxiety during stressful situations.

In one large meta-analysis review, researchers found that Omega-3 fatty acids EPA and DHA were associated with an improvement in anxiety symptoms, with greater benefits recorded in those with diagnosed anxiety problems.(12)

Tip: Fish oil is a common source of Omega-3s, but today's more advanced supplements are tending to supply Omega-3s from clean, vegan sources, such as marine algae.

Magnesium for Anxiety- Best Mineral for Relaxation

Magnesium is an essential mineral with a broad range of physiological functions, and emerging research suggests that it may play a valuable role in managing anxiety.

Magnesium plays a role in regulating neurotransmitters that are related to stress, anxiety and relaxation, including serotonin and GABA. It also helps to relax muscles and improve sleep quality, which can further assist with anxiety.

In one study, researchers found that magnesium supplementation was an effective therapy for helping people with mild-to-moderate depression to improve their mood.(13)

In a separate systematic review, researchers suggested that magnesium may aid anxiety reduction, but noted that more research is needed.(14)

L-Tryptophan

L-Tryptophan is an essential amino acid that plays a crucial role in the synthesis of serotonin, a neurotransmitter closely associated with feelings of relaxation, contentment, and a sense of well-being.

When there is a low supply of L-Tryptophan in the body, it can lead to reduced serotonin production, potentially contributing to an increased susceptibility to anxiety and mood disorders.

Researchers have reported that intake of L-Tryptophan may be closely related to reducing depressed and anxious mood states.(15)

With this research in mind, it seems that by increasing serotonin production, L-Tryptophan as a nootropic supplement may help alleviate stress and lower anxiety symptoms, such as worry, restlessness, and tension.

Best Supplements for Anxiety in 2025

The above list discusses some of the most effective single-ingredient nootropics on the market today. Next, let's cover some of the best supplements on the market today that deliver these nootropic ingredients to you.

Mind Lab Pro® supplies all the best nootropics for anxiety in one stack.

The creators of this product have expertly combined 11 well-researched nootropics, including several of the best anti-anxiety nootropics. Each ingredient helps to support brain function and cognitive function in many different ways:

• Citicoline, 250 mg
• Phosphatidylserine (PS), 100 mg
• Bacopa monnieri, 150 mg (full-spectrum extract, 24% bacosides with 9 bioactives)
• Organic Lion's Mane Mushroom, 500 mg (fruit and mycelium)
• Maritime Pine Bark Extract, 75 mg: (Standardized to 95% proanthocyanidins)
• N-Acetyl L-Tyrosine, 175 mg
• L-Theanine, 100 mg
• Rhodiola rosea, 50 mg (Standardized to 3% rosavins and 1% salidrosides)
• NutriGenesis® B-Vitamins: Vitamin B6 (2.5 mg), Vitamin B9 (100 mcg), Vitamin B12 (7.5 mcg)

As a result of its far-reaching design, MLP functions as a whole-brain optimizer, capable of boosting any aspect of cognition, mental wellness, and overall brain health as needed.

For mood health, MLP may ease social anxiety, elevate mood, help with reducing stress and generally reduce anxiety symptoms overall.

Because it is a whole-brain optimizer, MLP® can help in many other ways too. In fact, it flexes to deliver the cognitive support you need, when you need it. In the context of mood, for example:

• Anxiety can sap your mental energy. MLP® helps clear mental fatigue and brain fog.
• If anxiety and acute stress interfere with your daily drive, MLP® helps promote motivation naturally.
• Social anxiety and performance anxiety may be holding you back. MLP® supplies adaptogen herbs and amino acids that help you to perform under pressure.

Beyond helping to reduce anxiety and offering stress relief, MLP® helps with focus, attention, concentration, memory, mental clarity and pretty much any other aspect of cognition you can think of.

MLP® is also one of the very few nootropics for anxiety that is actually backed by human research:

• Study 1: Subjects taking MLP showed significant improvements (compared to placebo) in information processing tasks.(16)
• Study 2: Subjects taking MLP had significant improvements across multiple memory functions, including auditory, visual, visual working, immediate and delayed recall memory.(17)

Pricing & Shipping

• 1 Bottle (one month supply): $69 ($2.30/serving)
• 2 bottles (two month supply): $138 ($2.30/serving)
• Best deal: 3 bottles + 1 free, with free shipping: $207 ($1.73/serving)
• All covered by 30-day money back guarantee

Additional Top Nootropic Supplements for Anxiety

Mind Lab Pro® supplies most of the best nootropics discussed in this article. The rest can be found in products at Performance Lab®, a supplement line by the creators of Mind Lab Pro®.

Performance Lab® Prebiotic

Performance Lab® Prebiotic is a top supplement to take for gut health great for heart and digestive health, as well as for healthy immune function.

It also works as a nootropic by boosting the microbiome "second brain" for mood support. Each serving supplies:

• Inulin-FOS (as Orafti® Synergy1) (FructoOligoSaccharides from Chicory Root), 2 g

Chicory root in Performance Lab® Prebiotic feeds Lactobacillus and Bifidobacterium probiotic strains in the gut.

These particular probiotic strains have the strongest nootropic effects: They support healthy levels of "feel good" brain chemical serotonin and are suggested to help with anxiety and depression.

Learn more about Performance Lab® Prebiotic

Performance Lab® Omega-3

This nootropic supplement supplies clean, high-quality vegan Omega-3 fatty acids from Algal Oil, including DHA, the most important Omega-3 fatty acid to take as a brain supplement.

Performance Lab® Omega-3 is today's most sophisticated "healthy fat" supplement. Each serving of three NutriGels® supplies 1800 mg of vegan algal oil from life's™OMEGA, which includes:

• DHA (Docosahexaenoic Acid), 540 mg
• EPA (Eicosapentaenoic Acid), 270 mg

The Omega-3s DHA and EPA are considered brain-healthy nootropics, with DHA suggested to ease depression and support a brighter, more balanced mental state.

Mood is just one benefit of these remarkably versatile nutrients. As nootropics, Omega-3s help with overall brain health -- but they are also great for immune support, heart health, joint comfort and more.

Learn more about Performance Lab® Omega-3

Performance Lab® Sleep

Can you imagine a supplement that helps you out when anxiety is interfering with your sleep? Performance Lab® Sleep is it.

This supplement is driven by cherry extract, which supplies natural melatonin for inducing sleep. It also includes some top nootropics for anxiety: two forms of magnesium, L-Tryptophan, and Sea Buckthorn, which is a natural source of serotonin. Sleep supplies:

• Magnesium (as Magnesium Bisglycinate and NutriGenesis® Magnesium), 100 mg
• CherryPURE® (Whole Montmorency Tart Cherry) (50:1 concentrated ratio), 500 mg
• L-Tryptophan, 250 mg
• Organic Sea Buckthorn (Hippophae rhamnoides), 100 mg

The resulting formula supports sleep in many ways, including relaxing muscles, calming the nervous system, and potentially helping with anxiety, including anxiety caused by sleep deprivation.

And, because it promotes sleep with low-dose natural melatonin, Performance Lab® Sleep avoids the groggy hangover that you might get with synthetic megadose melatonin supplements.

Learn more about Performance Lab® Sleep

Summary

Whether you're struggling performance anxiety, social anxiety, or some other form of worry, there are many research-backed nootropics that may help anxiety management -- especially the high-quality formulations discussed in this article.

But a great nootropic should only be part of your overall anti-anxiety lifestyle changes. Exercising more, avoiding smoking and too much alcohol, practicing deep breathing, limiting caffeine intake, and practicing general self-help can also help relieve stress and reduce feelings worry, so you can live your best life with less anxiety.