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Phosphatidylserine (PS)

By Dr. Ramon Velazquez Ph.D.

Mind Lab Pro®
Phosphatidylserine (PS) 100 mg
as Sharp-PS® Green

Phosphatidylserine (PS) is a phospholipid highly concentrated in the brain, where it optimizes the formation and function of brain cell membranes. PS may be the most evidence-backed nootropic for memory.*

Brain Support

  • Promotes formation of fluid, healthy brain cell membranes.*
  • Optimizes brain cell membrane function, including neurotransmission.*
  • Helps with brain cell regeneration, maintenance and repair.*
  • Required for the production of brain cells' myelin sheaths.*

Nootropic Effects

  • Supports short- and long-term memory performance.*
  • Promotes learning and recall.*
  • Maintains clarity, mood, concentration and focus.*
  • May help with mild memory issues associated with aging.*

Mind Lab Pro®'s Phosphatidylserine as Sharp-PS® Green

  • Sharp-PS® Green is premium branded phosphatidylserine derived from natural sunflower lecithin; a 100% soy-free PS supplement.
  • Sharp-PS® Green is made with a patented, eco-friendly process.
  • Mind Lab Pro®'s 100 mg Sharp-PS® Green dosage > many standalone PS supplements.

Why Mind Lab Pro® includes PS

Phosphatidylserine (PS) is a phospholipid building block compound that is used to form cell membranes throughout the body. PS is most concentrated in the brain, where it comprises 15% of total phospholipids.1

In the brain, PS plays two important roles for healthy growth and function that may have far-reaching effects on overall brainpower:

  1. PS helps keep brain cell membranes fluid and flexible. Healthy cell membranes perform dynamically, directing cell-to-cell communications and more.2  In optimizing brain cell membranes, PS supports the neurotransmission that drives all types of thinking and memory.3
  2. PS supplies a key phospholipid building block that is required for brain regeneration, building and repair, including neurogenesis, brain plasticity and myelin sheath formation.4,5

PS is Mind Lab Pro®’s flagship nootropic for memory performance, but its complex roles in brain cell membrane processes may enhance all types of thinking while optimizing long-range brain health.

In a literature review published in 2015, researchers suggested that PS appears to support various human cognitive functions, including:6

  • Formation of short-term memory.
  • Consolidation of long-term memory.
  • Memory creation and retrieval.
  • Attention and concentration.
  • Reasoning and problem solving.
  • Language and communication skills.

How Phosphatidylserine (PS) may help with brain health and mental performance

Brain Regeneration

PS is a building block phospholipid nutrient that helps with brain cell creation, maintenance and repair. It is especially important for the formation of cell membranes. Decline of phospholipids like PS in brain cell membranes has been linked with brain degeneration, including age-related cognitive decline.7

Brain Protection

When brain cells shut down, they become toxic. PS sends out a signal that alerts the immune system to collect and dispose of the degrading brain cells before they turn dangerous – helping to protect neighboring cells from toxic damage.8,9

PS has also been suggested to help protect brain and body from the negative effects of stress, potentially by blunting release of the stress hormone cortisol.10  PS's anti-stress effects have been suggested to assist with mood and mental clarity.11

Brain Energy

One human study linked PS supplementation to a significant increase of brain glucose metabolism, including a 20.3% increase in the basal ganglia/thalamus and a 19.3% increase in the visual cortex.12

Brain Chemicals

Animal research suggests PS helps stimulate acetylcholine neurotransmitter production. PS’s support for brain cell membrane function may further help brain chemicals; healthy cell membranes facilitate healthy neurotransmission.13

Phosphatidylserine (PS) is the only nootropic with an FDA-qualified health claim, which reads:

  • "Phosphatidylserine (PS) may reduce the risk of cognitive dysfunction in the elderly. Very limited and preliminary scientific research suggests that PS may reduce the risk of cognitive dysfunction in the elderly. FDA concludes there is little scientific evidence supporting this claim.*"

Mind Lab Pro® Stack Strategy: Phosphatidylserine (PS) + Rhodiola Rosea for Competitive Cognition in Sports

PS is often associated with age-related memory benefits, but may be emerging as a nootropic sports nutrient. Research has linked PS to a reduction in perceived stress that improved golf scores; as well as improved resistance to exercise-induced stress that extended time to exhaustion during training.14,15

Rhodiola rosea is another nootropic that strengthens stress resistance and enhances athletic performance. Rhodiola has been used traditionally by Russian athletes in powerlifting and biathlon competitions, and has been shown to improve the body's ability to adapt to exercise.16

  • Together in Mind Lab Pro®, the nootropics PS and Rhodiola combine to support the healthy stress responses and mental clarity that help contribute to peak performance during athletic competition.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


  1. Jäger et al. Phospholipids and sports performance. J Int Soc Sports Nutr. 2007; 4:
  2. http://learn.genetics.utah.edu/content/cells/membranes/
  3. Vance JE. Thematic Review Series: Glycerolipids. Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids. July 2008 The Journal of Lipid Research, 49, 1377-1387]
  4. Hanahan DJ, Nelson DR. Phospholipids as dynamic participants in biological processes. J Lipid Res. 1984;25:1528–1535.
  5. Morell P, Quarles RH. Characteristic Composition of Myelin. Basic Neurochemistry: Molecular, Cellular and Medical Aspects. 6th edition. 1999
  6. Glade MJ, Smith K. Phosphatidylserine and the human brain. Nutrition. 2015 Jun;31(6):781-786.
  7. Wells K, et al. Neural membrane phospholipids in alzheimer disease. Neurochemical Research. November 1995, Volume 20, Issue 11, pp 1329–1333
  8. De Simone R, Ajmone-Cat MA, Tirassa P, Minghetti L. Apoptotic PC12 Cells Exposing Phosphatidylserine Promote the Production of Anti-Inflammatory and Neuroprotective Molecules by Microglial Cells. J Neuropathol Exp Neurol. 2003 Feb;62(2):208-16
  9. Schlegel RA, Williamson P. Phosphatidylserine, a death knell. Cell Death Differ. 2001 Jun;8(6):551-63.
  10. Monteleone P, Beinat L, Tanzillo C, Maj M, Kemali D. Effects of Phosphatidylserine on the Neuroendocrine Response to Physical Stress in Humans. Neuroendocrinology. 1990;52:243–248.
  11. Benton D, Donohoe RT, Sillance B, Nabb S. The Influence of Phosphatidylserine Supplementation on Mood and Heart Rate when Faced with an Acute Stressor. Nutr Neurosci. 2001;4:169–178.
  12. Klinkhammer P. Effect of Phosphatidylserine on Cerebral Glucose Metabolism in Alzheimer's Disease. Dement Geriatr Cogn Disord 1990;1:197–201
  13. Pepeu G, Spignoli G. Nootropic drugs and brain cholinergic mechanisms. Prog Neuropsychopharmacol Biol Psychiatry. 1989;13 Suppl:S77-88.
  14. Jäger R, et al. The effect of phosphatidylserine on golf performance. J Int Soc Sports Nutr. 2007 Dec 4;4:23.
  15. Kingsley M, Miller M, Kilduff LP, McEneny J, Benton D. Effects of phosphatidylserine on exercise capacity during cycling in active males. Med Sci Sports Exerc. 2006;38:64–71.
  16. Parisi A, et al. Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results. J Sports Med Phys Fitness. 2010 Mar;50(1):57-63.

These statements have not been approved by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

This article is an opinion and explanation of current research given by the author. It is not an expression of a medical diagnosis or treatment and should not be relied on as such.

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The statements on this page have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent disease.