Brain health has been a mainstay dietary supplement category for decades. But times have changed. Now peak cognitive performance is more important than ever, too. As a result, today's best brain supplement combines elements of neural health and mental performance.
Mind Lab Pro has earned its title as the top supplement for the brain by addressing not only traditional brain supplement roles -- such as brain health and age-related memory -- but also expanding the scope to include nootropic benefits for attention, mood, focus, energy and other cognitive functions.
In this article, we take a journey through Mind Lab Pro's development and features to understand why it is considered today's gold standard brain supplement. Let's get to it!
Key Takeaways
- The best dietary supplements for the brain must be backed by human clinical research demonstrating real benefits. The more research, the better.
- Formulation strategy is another hallmark of the best brain health supplements: combining nutrients that work well at nourishing the brain when combined.
- The brain is incredibly complex, so a versatile brain supplement that boosts the brain in many ways is preferred.
- Top brain supplements must maintain or enhance brain health, not merely boost short-term brainpower at the expense of brain health.
- Since research is always evolving, the best brain formula should be regularly updated to keep up with new scientific discoveries.
- Quality is huge when it comes to all dietary supplements, especially brain formulas. Poor quality limits results. Great quality amplifies results.
Disclaimer
Brain health concerns and brain-related medical conditions should always be evaluated and managed by your doctor. Specific diseases especially, such as Alzheimer's disease, require medical attention that only a doctor can provide. If you are considering taking supplements for your brain, be sure to consult with your doctor first.
What is a Brain Supplement?
A brain supplement is a dietary supplement that nourishes the brain. This got a little confusing, however, with the rise of nootropic supplements. Let's clarify with a simple distinction:
- Brain Supplements: Focus on long-term brain health to support cognitive function, protect against aging, and promote overall brain wellness.
- Nootropic Supplements:Target short-term cognitive performance by boosting functions like focus, memory, attention, and mental clarity.
Traditional brain supplements were formulated primarily to address issues related to overall brain health in a mature population, including helping with memory problems and age-related cognitive decline.
The more recent nootropic supplement era sparked a new dynamic, instead prioritizing specific cognitive functions above all. Learn more about nootropic benefits
Mind Lab Pro was introduced to combine the best of brain supplements and nootropics -- elevating the "brain pill" to a new space of 100% Brainpower.
Mind Lab Pro goes beyond traditional brain supplements. The MLP philosophy is based on the idea that the brain -- which is a highly intricate organ -- requires a holistic approach to ensure both health and sharp function in many ways.
Mind Lab Pro doesn’t just support the brain’s overall health -- it actively enhances mental performance in real-time. This is achieved through its groundbreaking combination of 11 research backed nootropics that meet the brain's complex needs in exciting new ways.
The result: MLP is a "Universal Nootropic" that can help anyone to boost any aspect of brainpower -- all while nourishing the brain for long-range health.
Let's take a closer look at how it works.
Six Pathways to Brain Enhancement
The human brain is a remarkably complex organ, with different areas responsible for a multitude of functions, from memory and decision-making to emotional regulation and creativity.
The best supplement for the brain, therefore, must take a broad-spectrum approach to supporting the brain. This is Mind Lab Pro's sweet spot.
Mind Lab Pro optimizes the brain across six biological pathways, each of which targets multiple aspects of mental performance and brain health:
- Neurotransmitters: Essential for memory, processing speed, focus, attention, creativity, and verbal acuity, neurotransmitters (also called brain chemicals) optimize the brain’s ability to communicate efficiently.
- Neural Regeneration: This pathway is designed to repair, maintain, and "fertilize" brain cells, promoting neuroplasticity and rapid growth -- helping mood, clarity and long-term cognitive health.
- Cerebral Circulation: By oxygenating the brain, clearing toxins, and boosting nutrient delivery, this pathway ensures that brain cells receive the fuel they need to function at their best.
- Neuroprotection: Nootropics with antioxidant effects work in this pathway to combat free radicals that damage brain cells and accelerate aging.
- Brain Waves: Enhancing "Alpha" brain waves helps to promote a calm, focused state that supports concentration, creativity, and a healthy mood. L-Theanine from green tea is best for this pathway.
- Energy Metabolism: This pathway is all about busting brain fog and mental fatigue to support alertness, quick thinking and focus. Brain energy is also a key contributor to overall brain health.
Learn more about how Mind Lab Pro works
By targeting six pathways at the same time, Mind Lab Pro optimizes the brain’s health, function, and performance -- achieving health-promoting, life-enhancing results that no other supplement can approach.
Stacking: The Power of Synergistic Formulation
In order to achieve its whole-brain boost and versatile benefits, Mind Lab Pro leverages the power of smart and strategic nootropic stacking. Stacking refers to the practice of combining different supplements or nutrients to enhance their overall effectiveness.
In the case of Mind Lab Pro, 11 ingredients have been carefully selected for their individual research-backed benefits as well as their complementary nature: these nootropics work very well as a team when combined.
MLP® Ingredients:
- Citicoline 250mg
- Phosphatidylserine (PS) 100mg
- Bacopa monnieri 150mg (24% bacosides)
- Organic Lion's Mane Mushroom 500mg
- Maritime Pine Bark Extract 75mg (95% proanthocyanidins)
- N-Acetyl L-Tyrosine 175mg
- L-Theanine 100mg
- Rhodiola rosea 50mg (3% rosavins and 1% salidrosides)
- NutriGenesis® Vitamin B6 (2.5 mg)
- NutriGenesis® Vitamin B9 (100 mcg)
- NutriGenesis® Vitamin B12 (7.5 mcg)
Learn more about Mind Lab Pro ingredients
The nutritional synergy of these 11 nootropics helps Mind Lab Pro provide a comprehensive brain boost, delivering results that far exceed what individual ingredients might offer on their own.
Mind Lab Pro is the Universal Nootropic because it helps anyone with any aspect of cognition: focus, attention, mood, mental alertness, working memory, stress related symptoms and more.
Top Single-Ingredient Brain Supplements
While the best brain product overall is a multi-ingredient stack, single-ingredient supplements can also be effective for brain health and function. Certain nutrients may be better as single-ingredient brain supplements, namely those where effective dosage is too big to fit in multi-ingredient stacks where low dose nootropics make sense. Examples of good single-ingredient brain supplements include:
- Omega-3 fatty acids. These crucial essential fatty acids for brain development are now available in vegan form for plant based diets (instead of from fatty fish oil). Omega-3 fatty acids, especially docosahexaenoic acid (DHA) are top choices for helping with depressive symptoms and brain health.
- Gut-boosting prebiotic fiber supplements support healthy neurotransmitters by feeding the colony of "good bacteria" in your gut.
- Vitamin D supplements. National Institutes of Health cites a systematic review suggesting low vitamin D levels raise risk for cognitive decline, depressive symtpoms and major depressive disorder.(1) Quality vitamin D supplements may help to lower risk and improve mood.
Note: While not a single-ingredient supplement, a top-quality multivitamin is another good supplement to consider to fill in nutritional gaps of key brain essential nutrients, including B-vitamins and magnesium.
Research: A Must-Have for the Best Brain Supplement
To be considered the best, a brain supplement must be supported by well-designed research studies. Test tube studies and animal research are a good foundation to start with. But ultimately, human research is the real test of a brain supplement's effectiveness.
Along those same lines, a stack supplement with strong research backing its individual ingredients is good... but well-designed human research studies backing the stack's unique nutrient combinations and dosages is way better.
Mind Lab Pro® delivers the best of both worlds, starting with 11 ingredients that have demonstrated brain health & cognitive function benefits across 145 human clinical trials.
Check out this infographic illustrating how many human research studies back each of MLP®'s 11 ingredients:
A really good brain supplement must start with reseach-backed nutrients. But a great supplement continues with research on the formulation itself.
Mind Lab Pro® (MLP) stands out as a leader in nootropic science, with three human studies (so far) demonstrating its effectiveness at boosting several cognitive functions.Here’s a summary of three important studies that back Mind Lab Pro® as the top choice for enhancing brain performance:
MLP® Study 1: Information Processing and Reaction Time.
A 2023 randomized controlled trial published in Biomedical Journal of Scientific & Technical Research investigated MLP's effects on information processing in healthy people. Over 30 days, participants who took MLP showed a 47% improvement in reaction time compared to a placebo group when performing cognitive tests.
Key tests like the Simple Reaction Time (SRT) and Choice Reaction Time (CRT) demonstrated that MLP significantly enhanced mental processing speed, focus, and decision-making abilities.(2)
These improvements are crucial for tasks requiring sharp cognition under pressure, positioning MLP as ideal for individuals in fast-paced environments.
Click here to read the full published MLP study as a PDF file
MLP® Study 2: Memory Enhancement.
A 2023 study published in Human Psychopharmacology: Clinical and Experimental examined the impact of MLP on memory.
The 30-day trial showed significant improvements in various types of memory, including a 28% boost in immediate recall and a 26% improvement in delayed recall. This study included 49 participants who took auditory, visual, and spatial memory tests, with MLP outperforming the placebo group across all metrics.(3)
The research suggests MLP is a leader for improving memory, helping to enhance everyday memory functions from remembering names to recalling important details.
Click here to read the full published MLP study as a PDF
MLP® Study 3: Brain Network Interdependence.
A 2025 study published in Brain Sciences explored how MLP affects brain network interactions. Participants took MLP for 60 days and underwent tests that measured decision-making speed and brain activity using EEG.
While decision performance remained similar, the study revealed that MLP promoted stronger cooperation between different brain regions, particularly in delta band brainwaves.(4)
These findings suggest that MLP enhances the underlying brain processes that support mental clarity, even in the absence of overt improvements in decision speed or accuracy.
Click here to read the MLP Study 3 in full
These studies provide convincing evidence that Mind Lab Pro® isn't just an effective brain supplement in theory -- its benefits are backed by human research studies.
Get details on the MLP Studies
With compelling evidence across multiple cognitive domains, studies suggest Mind Lab Pro® is the best brain formula available, setting a new benchmark for nootropic science.
Did you know? MLP has undergone 4 "formula upgrades" and is now on v4.0 -- another testament to this brain supplement's commitment to staying current with the latest scientific research breakthroughs.
Learn more about nootropics that actually work (according to science)
Quality: Clean, Premium, and Accessible for All
The best brain stack must be more than just effective -- it must also be made with the highest standards of quality to ensure daily use that is safe, healthy and well-tolerated.
In addition, clean-label supplements -- vegan, gluten-free, and free from fillers, allergens and additives -- ensure that people from all walks of life can access the best nootropics on the market in a single formula, even if they have sensitivities or dietary restrictions.
All of the compounds used in Mind Lab Pro are chosen for their efficacy in supporting brain health and performance. Other supplements for the brain fall short of MLP's research and development.
Another hallmark of the world's greatest brain supplement: All dosages are shown. Lesser brain supplements may hide their dosages in proprietary blends, making it impossible to know if they are hitting effective dosages. MLP shows all dosages to help people use it most effectively... and also simply because it's the right thing to do.
Mind Lab Pro's transparent, research-backed formulation guarantees that every ingredient serves a specific, evidence-based purpose, making it a safe and effective option for anybody seeking to improve mental performance, tune-up thinking skills and nourish long-range brain health.
Summary
Mind Lab Pro has truly earned its place as the best brain product on the market by addressing the multifaceted nature of brain health.
Certain supplements for the brain only target one or two goals. In the early days of brain supplements, main areas of support were for age-related cognitive impairment, brain health and better memory, primarily for older adults.
MLP, on the other hand, does it all. The game has changed since early brain supplements. That's why MLP supports both "traditional brain pill" functions like sharpening memory and improving brain health, while also enhancing mental performance through nootropic support.
Its holistic approach targets all six pathways of brain optimization, offering a comprehensive and well-rounded solution for anyone looking to support or enhance their brain function.
With its clean, premium quality and science-backed formula, Mind Lab Pro is the Gold Standard brain supplement for anyone seeking to improve mental clarity, focus, and overall brain health.
In the end, the best brain healthy supplements don't just support the brain in isolation -- they optimize all aspects of brain function and provide lasting, real-world benefits.
Mind Lab Pro is the brain supplement that meets this standard, delivering research-backed results you can feel. For best results, combine it with enough sleep, good exercise factors, and other factors that take a holistic approach to overall health.
References
- https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional
- Utley A, Gonzalez Y, Imboden CA. The Efficacy of A Nootropic Supplement on Information Processing in Adults: A Double Blind, Placebo Controlled Study. Biomed J Sci & Tech Res 49(1)-2023. Link
- Abbott-Imboden C., Gonzalez Y., Utley A. (2023). Efficacy of the nootropic supplement Mind Lab Pro on memory in adults: Double blind, placebo-controlled study. Human Psychopharmacology: Clinical and Experimental, e2872. Link
- O’Reilly, D., Bolam, J., Delis, I., & Utley, A. (2025). Effect of a Plant-Based Nootropic Supplement on Perceptual Decision-Making and Brain Network Interdependencies: A Randomised, Double-Blinded, and Placebo-Controlled Study. Brain Sciences, 15(3), 226. Link
