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Vitamin B9

By Dave Wright

Mind Lab Pro® supplies:
Vitamin B9 100 mcg

as BioGenesis™ nature-identical

Vitamin B9 is an essential nootropic vitamin that supports cerebrovascular function for overall brain health and neurotransmitters that regulate mood, memory and mental performance.*

Brain Support

  • Supports brain chemicals associated with a bright, healthy mood*
  • Regulates blood homocysteine that interferes with cerebral circulation*

Nootropic Effects

  • Optimizes brain health for long-range memory and mental performance*
  • Suggested to help promote social function, concentration and alertness*

Mind Lab Pro® Vitamin B9

  • Premium BioGenesis™ Vitamin B9 as nature-identical, whole-food folate
  • BioGenesis™ folate efficiently converts into active nootropic L-methylfolate
  • L-methylfolate is 4X more concentrated in the brain than the bloodstream
  • Clean, eco-friendly B9 grown on cultures in a state-of-the-art laboratory
  • Superior to synthetic folic acid form of B9 used in some nootropic stacks

Why Mind Lab Pro® Includes Vitamin B9

Vitamin B9 is an essential nutrient for overall brain health. In infancy, it is critical for healthy brain development; in adulthood, it maintains healthy cognitive function, largely due to its role in regulating homocysteine.

Suboptimal Vitamin B9 levels can result in high homocysteine, which in turn contributes to age-related cognitive decline, mood imbalance and poor mental performance.<1>

  • Mind Lab Pro® supplies Vitamin B9 to balance homocysteine levels, thereby optimizing blood flow to the brain and production of neurotransmitters needed for healthy memory, mood and mental processing.

How Vitamin B9 may help with brain health and mental performance

Brain Circulation + Brain Protection

Homocysteine in the bloodstream increases vascular oxidative stress, irritates and damages blood vessel linings, and affects blood clotting pathways – creating health concerns for the healthy cerebrovascular function that is critical for cognitive performance.<2,3,4>

High homocysteine levels correlate to low B9 intake;<5> both of which are tied to cognitive decline and unhealthy changes to brain structure.<6>

  • In supplement form, Vitamins B6, B9 and B12 – all found in Mind Lab Pro® – have been shown to effectively reduce blood homocysteine levels.<7>

Vitamin B9 as folate helps to convert homocysteine to methionine – helping to reduce blood homocysteine levels to a healthier range associated with sharp mental performance.<8>

In regulating homocysteine, Vitamin B9 may help protect the blood-brain barrier’s microvascular system; high homocysteine can damage cerebral blood vessel linings and contribute to cognitive decline.

Brain Chemicals

Mind Lab Pro® Vitamin B9 as nature-identical folate efficiently converts into L-Methylfolate, the active nootropic form that enables the production of three important brain chemicals: Serotonin, norepinephrine and dopamine.<9>

Low folate levels have been linked to mood imbalance, with researchers suggesting folate supplementation may help by promoting healthy serotonin levels.<10>

In addition, folate acts as a methyl donor to help the body naturally synthesize S-Adenosyl-methionine (SAMe), a signaling compound tied to serotonin that may further support a bright, healthy mood.<11>

Mind Lab Pro® Stack Strategy: B9+B6+B12 for Homocysteine Balance and Cerebrovascular Health

Low Vitamin B9 (as folate) and high homocysteine levels are a modifiable risk factor for poor mental performance and cognitive decline, in part because high homocysteine interferes with healthy cerebrovascular function.

Meta-analysis of 12 clinical trials including over 1,100 study subjects has suggested that supplementation with .5 mg of Vitamin B9 appears to be associated with a 25% reduction in blood homocysteine concentrations; adding .5 mcg of Vitamin B12 to the supplementation regimen was associated with an additional 7% reduction in blood homocysteine levels.<12>

  • Mind Lab Pro® supplies all three of the B vitamins that are most associated with regulating homocysteine levels: Vitamins B6, B9 and B12. In doing so, Mind Lab Pro® addresses an important risk factor for long-range brain health and mental clarity.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


  1. Young SN, Ghadirian AM. Folic acid and psychopathology. Prog Neuropsychopharmacol Biol Psychiatry 1989;13:841-63.
  2. Welch GN, et al. (1995). Homocysteine, oxidative stress, and vascular disease. Hosp Pract;Jun 15;32(6):81-2, 85, 88-92.
  3. Selhub J. (1999). Homocysteine metabolism. Annu Rev Nutr.;19:217-46.
  4. Varga E, et al. (2005). Homocysteine and MTHFR Mutations. Circulation; 111: e289-e293.
  5. http://lpi.oregonstate.edu/mic/vitamins/folate
  6. Smith AD, Refsum H. Homocysteine, B Vitamins, and Cognitive Impairment. Annu Rev Nutr. 2016 Jul 17;36:211-39
  7. Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review. Nutrients. 2016 Feb; 8(2): 68.
  8. Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol. 2006;5:949–960.
  9. Leahy LG. Vitamin B Supplementation: What's the Right Choice for Your Patients? J Psychosoc Nurs Ment Health Serv. 2017 Jul 1;55(7):7-11.
  10. Young S. Folate and depression—a neglected problem. J Psychiatry Neurosci. 2007 Mar; 32(2): 80–82.
  11. Bottiglieri T. Folate, vitamin B₁₂, and S-adenosylmethionine. Psychiatr Clin North Am. 2013 Mar;36(1):1-13.
  12. Homocysteine Lowering Trialists’ Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. BMJ. 1998 Mar 21; 316(7135): 894–898.

These statements have not been approved by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

This article is an opinion and explanation of current research given by the author. It is not an expression of a medical diagnosis or treatment and should not be relied on as such.

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The statements on this page have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent disease.