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List of Nootropics - 85 Brain-Boosters, 11 Best-in-Class, 1 Universal Stack

By Dave Wright

Nootropics are complicated. By strict definition, only a handful exist. But today, the meaning of "nootropic" has expanded to include anything that affects the brain -- regardless of whether it is safe and effective. The following list of nootropics focuses on this general brain supplement category.

After taking a broad view of the nootropic landscape, we zoom in to a shorter list of 11 true nootropics that work, safely and effectively -- culminating in the one nootropic stack that may deliver all brain benefits.

List of Nootropics

This list presents 85 supplements that are related to the brain -- including all of the most effective nootropics you can buy on the market.

Keep in mind, however, that not all of the nootropics listed below are shown to be effective. In fact, not all of them meet the true definition of nootropic. We'll give more details on true nootropics later in this guide.

For each nootropic on this list, there is one reference. This reference does not suggest if a nootropic works or not -- but it does explain why it may be categorized as a nootropic, as well as serving as a starting point for additional research. The list of nootropics follows:

  1. 5-HTP - amino acid that regulates serotonin and other brain chemicals for relaxation, sleep, and appetite satisfaction<1>
  2. Acetyl L-Carnitine – antioxidant suggested to protect and power brain cells; may help age-related cognitive issues<2>
  3. Alpha Lipoic Acid - fat-soluble antioxidant that can cross the blood-brain barrier and help protect the brain against aging<3>
  4. Alpha-GPC - phospholipid choline source suggested to support brain structure and brain chemicals; used for age-related cognitive decline<4>
  5. Aniracetam - synthetic Russian racetam primarily used for memory and mood in the elderly<5>
  6. Apoaequorin - jellyfish protein used for neuroprotective activity; brand-sponsored research showed benefits for memory and focus<6>
  7. Artichoke - supplies luteolin, an active ingredient that may balance the cAMP that regulates memory and mental performance<7>
  8. Ashwagandha - adaptogen root herb with benefits for mental energy, stress resistance and mood; may also help with healthy brain aging<8>
  9. Astaxanthin – potent antioxidant found in algae and seafood that may offer some brain-protective activity, especially in the context of aging<9>
  10. Bacopa monnieri – best nootropic herb for students, shown to improve retention of knowledge and strengthen stress resistance<10>
  11. Caffeine – not a true nootropic, but a stimulant that boosts alertness and almost always is accompanied by a subsequent crash<11>
  12. California poppy - suggested to interact with GABA and HTP receptors for anxiety-soothing effects; also helps sleep<12>
  13. Cat’s Claw - South American vine herb with early research suggesting neuroprotective activity that may help with brain aging<13>
  14. Catuaba – traditional Brazilian bark herb suggested in early animal research to have neuroprotective potential  <14>
  15. CBD – cannabis derived compound that is suggested to ease anxiety and possess some neuroprotective effects  <15>
  16. Celastrus paniculatus -  woody shrub seeds used in Ayurvedic herbalism; animal research suggests it may help overall brain health <16>
  17. Centrophenoxine - synthetic smart drug related to DMAE suggested in animal research to help brain energy and cerebral vascular function<17>
  18. Citicoline – best overall nootropic choline source for brain energy and healthy brain structure; shown to help focus, attention, memory, mood<18>
  19. Clitoria ternatea - traditional Asian herb suggested in animal research to have memory-enhancing nootropic effects<19>
  20. Coluracetam - otherwise called MKC-231, a rarely seen synthetic racetams created to help with brain degeneration<20>
  21. Convolvulus pluricaulis - Indian tonic herb and Ayurvedic brain-booster; suggested to help learning, mood and memory in animal research<21>
  22. CoQ10 - coenzyme pseudo-vitamin that helps brain health by powering up brain cell mitochondria and supplying anti-aging antioxidant activity<22>
  23. Creatine - popularly used by athletes to charge-up their muscles, may work in the same way in the brain to enhance mental energy<23>
  24. Choline - similar to B vitamins and related to lecithin, it declines with age but is important for brain chemical acetylcholine and maintaining healthy brain structure<24>
  25. DHA - essential fatty acid that is crucial for early brain development and helpful for sharp cognition in old age<25>
  26. DMAE - found in sardines, helps to optimize brain cell structure and has been suggested to help with attention, mood and cognitive decline<26>
  27. Forskolin - active ingredients of Coleus Forskohlii, promotes cAMP molecules that helps regulate cell to cell communication, mood and memory storage<27>
  28. GABA - inhibitory amino acid that settles nerves producing relaxation and pleasant mood, suggested to help with sleep and potentially attention<28>
  29. Ginkgo biloba – ancient Chinese wellness herb enhances brain circulation, strong reputation for helping with memory and age-related cognitive performance<29>
  30. Ginseng - adaptogen herb that supports brain chemicals and cAMP while countering stress; energizes mental and physical performance<30>
  31. Gotu Kola - traditional Chinese herbal best known for its blood vessel support; maintains circulation to the brain to promote memory and mood, especially in the elderly<31>
  32. Guarana - South American Berry that is one of the best natural sources of caffeine, traditionally used to boost mind energy and physical endurance<32>
  33. Huperzine-A - synthetic alkaloid from Chinese club Moss, used to sustain acetylcholine levels and shown to help with memory and degenerative brain concerns<33>
  34. Kanna (Sceletium tortuosum) - South African herb shown in research to help with mental performance in seniors with brain degeneration<34> 
  35. Kava Kava - psychoactive root herb used in traditional South Pacific ceremonies; may help promote relaxation, ease anxiety and improve sleep<35>
  36. Kratom – controversial legality and questionable safety; a traditional Asian herb that is believed to promote feelings of calmness and positivity<36>
  37. L-Glutamine - amino acid that supports glutamate, a key brain chemical for healthy cognition; may also help to protect the brain<37>
  38. L-Phenylalanine - amino acid that is a precursor to many of the brain chemicals needed for sharp, clear mental function and mood balance and<38>
  39. L-Theanine – green tea amino acid that raises Alpha brain waves to promote wakeful relaxation for creativity and productivity; also shown to support sharp mental clarity during aging<39>
  40. L-Tryptophan - precursor to five HTP that helps enhance brain chemicals for calm, relaxed moods; also influences melatonin and has been shown to improve sleep quality<40>
  41. Lecithin - phospholipid found in egg yolk that supplies choline that in turn forms acetylcholine brain chemical while optimizing brain cell healthy structure<41>
  42. Lemon Balm - traditional herb that regulates brain chemicals and their receptors to promote calmness and induce sleep<42>
  43. Lion’s Mane Mushroom – raises nerve growth factor to help with brain plasticity, regeneration and repair; shown to enhance mood<43>
  44. Magnolia - bark herb supplies active honokiol, which is suggested to balance brain chemistry for relaxation without sedation<44>
  45. MCT Oil – supports the use of ketones for brain energy instead of carbohydrates; helpful for mental clarity on keto diet<45>
  46. NADH - antioxidants coenzyme related to vitamin B3 tha t is required for ATP energy production; also supports the brain chemical dopamine<46>
  47. Nefiracetam - synthetic racetam smart drug linked with brain chemicals and suggested for helping with age-related memory and cognitive issues<47>
  48. Nicotine – hard to classify it as a nootropic, but nicotine has shown nootropic effects in the realm of brainpower<48>
  49. Noopept - patented racetam, little research suggests it may have stimulating effects that help with cognitive function<49>
  50. Oatstraw - increases Alpha brain waves associated with a state of relaxed alertness<50>
  51. Oxiracetam - stimulating racetam used for acetylcholine; may help memory and focus<51>
  52. Passionflower - traditional herb with calming properties, believed to balance brain chemicals for relaxation and healthy sleep<52>
  53. Phenibut - controversial synthetic nootropic appears to regulate dopamine; suggested to help with mood issues<53>
  54. Phenylpiracetam - considered one of the harsher and more powerful racetams, suggested to help with higher-order cognitive function<54>
  55. Phosphatidylcholine - phospholipid nootropic that is key for brain regeneration; linked to benefits for memory, mood and overall brain health<55>
  56. Phosphatidylserine (PS) – multitasking phospholipid that helps build, power and protect brain cells; best evidence-backed nootropic for memory<56>
  57. Picamilon - synthetic compound that binds GABA with niacin; suggested to help with attention and anxiety, but complex legal status<57>
  58. Pine Bark Extract – antioxidant complex protects the brain and blood vessels; also promotes nitric oxide to boost blood flow to the brain; suggested to help with attention and overall brain health<58>
  59. Piracetam - the original racetam, and the first “nootropic” – optimizes brain chemicals for stimulating, mood balancing effects<59>
  60. Psychobiotics – The gut and the brain are closely connected, and science is discovering that beneficial flora in the GI tract can influence mood and cognitive function<60>
  61. Pramiracetam - racetam suggested to help with acetylcholine; may help with memory formation and recall<61>
  62. Pterostilbene - antioxidant found in berries believed to help strengthen the brain’s resistance to aging<62>
  63. PQQ - super antioxidant that is required for the production of energy within brain cells mitochondria; suggested to help with overall brain health during the aging process<63>
  64. Resveratrol - red wine antioxidant that helps to support healthy brain aging by protecting brain cells against free radicals and inflammation<64>
  65. Rhodiola rosea – legendary adaptogen root herb from Russia that optimizes mental energy and physical endurance by regulating the body’s stress responses<65>
  66. Rosemary – Worn as wreath by students in ancient Greece because its aroma sharpens focus; modern uses include age-related cognitive support<66>
  67. SAMe - catalyzes and supports several brain functions, including cell signaling and cell membrane function; most popularly used to support mood balance <67>
  68. Schizandrol-A - Asian berry supplies this active ingredients suggested to have anti-stress activity and to help protect the brain<68>
  69. St. John’s Wort - bright flower herb supplies active hypericin and hyperforin, which balance brain chemicals related to mood; good research profile for helping with depression<69>
  70. Sulbutiamine - synthetic vitamin B1 that is molecularly altered to make it fat-soluble and capable of crossing the blood brain barrier; may help general brain health<70>
  71. Taurine - amino acid that regulates cell to cell communication, often seen in energy drinks though the only evidence suggests nerve-calming effects<71>
  72. Theobromine – Caffeine-like compound sourced from cocoa believed to have stimulating properties with fewer side effects<72>
  73. Turmeric - root herb supplies antioxidant complex linked to brain cell protection and long-range cognitive health<73>
  74. Tyrosine – precursor used to form brain chemicals tied to attention and focus; shown in research to enhance multiple aspects of mental performance in distracting, multitasking settings. <74>
  75. Uridine - raw material that is used by the body to make brain-supportive choline and acetylcholine; suggested to have potential for brain regeneration<75>
  76. Valerian - ancient root herb that may work by sustaining GABA (soothing brain chemical) levels to promote relaxation and ultimately, sleep<76>
  77. Vinpocetine – synthetic form of periwinkle that has a complex legal status but is one of the best brain circulation boosters<77>
  78. Vitamin B1 (Thiamine) - low levels may be linked to pour cognitive performance; suggested to help brain chemicals to function properly<78>
  79. Vitamin B3 (Niacin) - suggested to have roles and brain chemical synthesis and brain protection; may help with healthy brain function later in life<79>
  80. Vitamin B5 (Pantothenic Acid) - suggested as part of a multivitamin to help with attention-related issues, although evidence is conflicted<80>
  81. Vitamin B6 - contributes to nerve sheathing, blood vessel flexibility and brain chemical conversion and synthesis<81>
  82. Vitamin B8 - also called inositol, helps with brain cell membrane synthesis and optimizes some neurotransmitters, mainly serotonin<82>
  83. Vitamin B9 - plays a key role in regulating homocysteine levels in the blood, thereby supporting cerebrovascular health<83>
  84. Vitamin B12 - raw material for nerve-protective myelin, also a key player in brain energy; suggested to help maintain brain volume during aging<84>
  85. Yerba Mate – Traditional herb that is brewed into a stimulating tea with focus-enhancing support<85>

11 Best-in-Class Nootropics

Out of 85 brain supplements that are called nootropics, far fewer are true nootropics.

Only the best of the best have research-backed benefits for brain health, brain protection and mental performance while remaining safe and side effect-free.

Here is a list of best-in-class brain boosters are considered true nootropics:

Citicoline as Cognizin®

  • Choline source that raises levels of brain-building phosphatidylcholine (PC)
  • Promotes brain chemical acetycholine for mood and mental performance
  • Shown to optimize mitochondria and increase brain energy by 13.6%
  • Shown to boost brain cell membrane regeneration by 26%
  • Promotes mood balance, memory, attention, focus and concentration
  • Helps to protect the brain against age-related structural changes


Cognizin® is the best citicoline form: Superior-quality, 99%+ pure citicoline made with a patented process. Extensively researched; shown to be a safe and effective nootropic. More on Citicoline


Phosphatidylserine (PS) as Sharp PS® Green

  • Building-block nootropic with versatile brain-supportive bioactivities
  • Found in brain cell membranes, where it helps maintain fluidity
  • Regulates brain chemicals like acetylcholine and dopamine
  • Optimizes brain energy metabolism by enhancing glucose uptake
  • Helps raw materials and growth factors for brain cell creation and repair
  • Best evidence-backed nootropic for short-term and long-term memory
  • May sharpen memory, slow cognitive decline and promote mood in elderly
  • Studied as a sports nutrition supplement for focus
  • Suggested to help with mood and overall mental clarity
  • Supports long-range brain health
Sharp PS® Green is the best PS form. It is notably soy-free; other forms are soy-based. Sharp PS® Green is made from Non-GMO sunflower lecithin using patented eco-friendly methods. More on Phosphatidylserine (PS)

Bacopa Monnieri, 24% bacosides and 9 bioactives

  • Ayurvedic cognitive herb that supplies active nootropic bacosides
  • Supplies and amplifies cell-protective antioxidant activity in the brain
  • Promotes brain chemicals acetylcholine, GABA and serotonin
  • Animal research suggests it may boost cerebral blood flow by 25%
  • Supports memory performance, both short-range and long-range
  • Shown to slow the rate of forgetting newly acquired knowledge
  • Helps with mental processing, cognition under stress and relaxation
  • Best known as a nootropic for students and other learners
24% bacosides (calibrated for 9 bioactives) is the best Bacopa form. Standardized for Bacopa's active bacosides, it also targets 9 specific bacosides that bring brain benefits. More on Bacopa Monnieri 

Lion’s Mane Mushroom, Full Spectrum Extract

  • The only mushroom in nature with brain-boosting nootropic properties
  • Shown to stimulate Nerve Growth Factor (NGF) for brain regeneration
  • Suggested to support brain plasticity for learning and memories
  • Shown to help with mild age-related cognitive impairment
  • Shown to help maintain a balanced, healthy mood
Full-spectrum is the best form of Lion's Mane. Full-spectrum supplies the mushroom's active nootropics, which are called hericenones and erinacinesMore on Lion’s Mane Mushroom 

Maritime Pine Bark Extract, 95% proanthocyanidins

  • Potent antioxidant complex that can cross the blood-brain barrier
  • Helps protect the brain and cerebral blood vessels from free radical damage
  • Signals for nitric oxide (NO) to enhance blood flow to the brain
  • Brain regenerative potential for age-related cognitive and memory issues
  • Suggested help with mental energy, focus, attention and learning
  • Helps to promote long-range brain health, sharp memory and mental clarity
95% proanthocyanidins is a best-in-class Pine Bark Extract form. Maritime Pine Bark has a stronger antioxidant profile; 95% proanthocyanidins is the most potent available. More on Maritime Pine Bark Extract 

L-Tyrosine as N-Acetyl-L-Tyrosine (NALT)

  • Amino acid precursor to dopamine, epinephrine and norepinephrine
  • Assists with mental recovery after stress
  • Optimizes memory, mood and mental processing
  • Helps cognition under multitasking conditions
  • Enhances mental performance under stressful conditions
  • Maintains mental sharpness in times of sleep deprivation
  • Supports attention and focus
N-Acetyl-L-Tyrosine is the best form for brain health products: It is bioavailability-enhanced to deliver more nootropic activity than plain Tyrosine. More on N-Acetyl L-Tyrosine 

L-Theanine as Suntheanine®

  • Amino acid nootropic found in green tea
  • Increases activity of Alpha brainwaves
  • Promotes calm without sedation, known as wakeful relaxation
  • Balances calming brain chemicals: Serotonin, dopamine and GABA
  • Neuroprotective properties appear to help maintain brain health during aging
  • Commonly stacked with caffeine because it reduces its jittery side effects
Suntheanine® is the best form of L-Theanine. It supplies 100% pure L-isomer-Theanine and has been shown in human research to enhance Alpha brainwaves, mental clarity and sleep quality. More on L-Theanine 

Rhodiola Rosea, 3% rosavins, 1% salidrosides

  • Helps stimulate norepinephrine, dopamine, and serotonin
  • Acetylcholine-protective and antioxidant properties
  • Stimulates bioelectrical activity in the brain with small dosage
  • Adaptogen herb that strengthens mind-body stress resistance
  • Blunts the release of the stress hormone cortisol
  • Energizing effects within 30 minutes and may last for up to six hours
  • May help mental processing, learning, attention, mood and work capacity
3% rosavins and 1% salidrosides is the best Rhodiola form; this standardization of Rhodiola's active nootropics is research-backed for cognitive benefits. More on Rhodiola Rosea 

Vitamin B6 as BioGenesis™

  • Needed for synthesis of cognition-oriented brain chemicals
  • Helps with formation of myelin sheaths that protect neurons
  • Linked to memory and attention enhancement
  • Helps maintain healthy mood brain chemistry
  • Supports long-term brain health, memory and clarity
  • More on Vitamin B6

Vitamin B9 as BioGenesis™

  • Promotes mood-oriented brain chemicals
  • Helps balance homocysteine for good cerebral circulation
  • Supports long-range brain health and mental sharpness
  • Suggested to help with focus, alertness in socialization
  • BioGenesis™ B9 efficiently converts into active nootropic L-methylfolate
  • More on Vitamin B9

Vitamin B12 as BioGenesis™

  • Basic vitamin needed for overall nervous system health
  • Promotes formation of myelin nerve sheathing
  • Helps protect the brain against age-related shrinkage
  • Sharpens mental performance in cases of age-related cognitive decline
  • Supports brain energy metabolism
  • More on  Vitamin B12


BioGenesis™ is a form of vitamins and minerals grown on cultures in a clean, eco-friendly laboratory setting. This process creates nature-identical B-vitamins with full-spectrum cofactors and enzymes that enhance the nootropic potency, activity and effectiveness of B6, B9 and B12.

One Universal Nootropic

While reviewing the above 11 best-in-class nootropics, you may have asked yourself: What happens if I take all 11 of these at once?

With the pre-made stack nootropic supplement Mind Lab Pro®, you can find out.

Out of 80+ nootropics, Mind Lab Pro® selected the 11 best-in-class brain boosters on this list because they are:

  • Supported by strong evidence suggesting a diverse range of brain health benefits;
  • Complementary, working well as a team to enhance overall cognitive performance;
  • Safe, backed by abundant research demonstrating safety and tolerability

Mind Lab Pro® is formulated with these best-in-class nootropics in superior forms -- including advanced botanicals and branded nootropics with unique patented advantages.

This Universal Nootropic™ nootropic stacking strategy -- innovated by Mind Lab Pro® -- optimizes multiple brain pathways at once to promote overall brain health, enhance all types of thinking and unlock a peak-performing mental state known as 100% Brainpower:



list of nootropics in mind lab pro and how they create 100 percent brainpower From a long list of nootropics, Mind Lab Pro® chose 11 best-in-class brain-boosters that work in many ways to unlock the brain's full potential.


Mind Lab Pro® 's 11 best-in-class from this long list of nootropics forms a Universal Nootropic™ that boosts the whole brain.

This list of nootropics -- while not complete -- is a good at-a-glance representation of the vast number of potential brain-boosters that may be found in popular nootropic supplements. As nootropics continue to gain scientific validation, this list will only continue to grow.

For those seeking a nootropics list to find one brain-booster to try out, there are many good standalone options above.

For those researching nootropic lists to explore the potential of combining several into a powerful brain-boosting stack, Mind Lab Pro® is the ideal solution:

Mind Lab Pro® combines 11 best-in-class nootropics in upgraded forms into a true Universal Nootropic™ that works for everyone, is safe for everyone, and fits any lifestyle.


  1. Turner E, et al. Serotonin a la carte: Supplementation with the serotonin precursor 5-hydroxytryptophan. Pharmacology & Therapeutics (2005)
  2. Spagnoli A, Lucca U, Menasce G, et al. Long-term acetyl-L-carnitine treatment in Alzheimer’s Disease. Neurology 1991;41:1726-32
  3. Maczurek A, et.al. Lipoic Acid as an anti-inflammatory and neuroprotective treatment for Alzheimer’s disease. Advanced Drug Delivery Reviews. Volume 60, Issues 13-14. October-November 2008. Pages 1463-1470
  4. Parnetti L, et al. Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data. Mechanisms of Ageing and Development. Volume 122, Issue 16, November 2001, Pages 2041–2055
  5. Perng CH, et al. The treatment of cognitive dysfunction in dementia: a multiple treatments meta-analysis. Psychopharmacology (Berl). 2018 Mar 3. doi: 10.1007/s00213-018-4867-y.
  6. Moran DL, et al. Effects of a Supplement Containing Apoaequorin on Verbal Learning in Older Adults in the Community. Adv Mind Body Med. 2016 Winter;30(1):4-11.
  7. Wang H, et al. Ameliorating effect of luteolin on memory impairment in an Alzheimer’s disease model. Mol Med Rep. 2016 May; 13(5):4215-20
  8. Chandrasekhar K et al. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012 Jul;34(3):255-62.
  9. Katagiri M et al. Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomised, double-blind, placebo-controlled study. J Clin Biochem Nutr. 2012 Sep;51(2):102-7
  10. Roodenrys S, et al. Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology. 2002 Aug;27(2):279-81
  11. Ruxton, CHS. Cognitive function is not influenced by increasing caffeine dose. Nutrition Bulletin. 13 Feb 2008. 33: 15–25
  12. Fedurco M, et al. Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors. Biochem Res Int. 2015;2015:617620
  13. Mohamed AF, et al. Effects of Uncaria tomentosa total alkaloid and its components on experimental amnesia in mice: elucidation using the passive avoidance test. The Journal of pharmacy and pharmacology. 2000;52: 1553-1561
  14. Chassot JM, et al. Preclinical evaluation of Trichilia catigua extracts on the central nervous system of mice. J Ethnopharmacol. 2011 Oct 11;137(3):1143-8
  15. Crippa JA et al. Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. J Psychopharmacol. 2011 Jan;25(1):121-30.
  16. Bhanumathy M et al. Nootropic activity of Celastrus paniculatus seed. Pharm Biol. 2010 Mar;48(3):324-7
  17. Marcer D and  Hopkins SM. The differential effects of meclofenoxate on memory loss in the elderly. Age and ageing 1977, 6(2):123-131
  18. Silveri, et al. Cognizin® Citicoline Increases Brain Energy (ATP) by 14% and Speeds up Formation of Brain Membranes by 26% in Healthy Adults. Society for Neuroscience, San Diego California
  19. Rai KS, et al. Clitoria ternatea (Linn) root extract treatment during growth spurt period enhances learning and memory in rats. Indian J Physiol Pharmacol. 2001 Jul;45(3):305-13
  20. Murai S, et al. MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice. J Neural Transm Gen Sect. 1994;98(1):1-13.
  21. Dhingra D, et al. Evaluation of the antidepressant-like activity of Convolvulus pluricaulis choisy in the mouse forced swim and tail suspension tests. Med Sci Monit. 2007 Jul;13(7):BR155-61.
  22. Littarru GP1, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol. 2007 Sep;37(1):31-7. Retrieved from:
  23. McMorris T et al. Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol. Psychopharmacology (Berl). 2006 Mar;185(1):93-103
  24. Blusztajn JK. Neuroprotective Actions of Dietary Choline. Nutrients. 2017 Jul 28;9(8).
  25. Schaefer EJ. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Arch Neurol. 2006 Nov;63(11):1545-50.
  26. Ferris SH et al. Senile dementia: treatment with deanol. J Am Geriatr Soc. 1977 Jun;25(6):241-4
  27. Ando S, et al. Delayed memory dysfunction by transient hypoxia, and its prevention with forskolin. Brain Research. Volume 405, Issue 2:371–374. 10 March 1987
  28. Abdou AM, Higashiguchi S, Horie K, et al. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. Biofactors 2006;26:201-8.
  29. Rai GS, Shovlin C, Wesnes KA. A double-blind, placebo-controlled study of Ginkgo biloba extract (‘tanakan’) in elderly outpatients with mild to moderate memory impairment. Curr Med Res Opin 1991;12:350-5
  30. Reay JL, Kennedy DO, Scholey AB. Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained ‘mentally demanding’ tasks. J Psychopharmacol. 2006 Nov;20(6):771-81
  31. Wattanathorn J et al. Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica. J Ethnopharmacol. 2008 Mar 5;116(2):325-32.
  32. Kennedy DO, Haskell CF, et al. Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng. Pharmacol Biochem Behav. 2004 Nov;79(3):401-11
  33. Xu SS, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer’s disease. Zhongguo Yao Li Xue Bao. 1995 Sep;16(5):391-5
  34. Chiu S et al. Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer’s Dementia. Evid Based Complement Alternat Med. 2014;2014:682014.
  35. Sarris J, et al. Kava in the treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled study. Journal of Clinical Psychopharmacology. 2013 Oct;33(5):643-8.
  36. Suhaima W. Neurobiology of Kratom and its main alkaloid mitragynine. Brain Research Bulletin Volume 126, Part 1, September 2016, Pages 29-40
  37. Rae C et al. Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentation. J Neurochem. 2003 Apr;85(2):503-14
  38. Beckmann H, Athen D, Olteanu M, Zimmer R. DL-phenylalanine versus imipramine: a double-blind controlled study. Arch Psychiatr Nervenkr (1970). 1979 Jul 4;227(1):49-58
  39. Kakuda T, et al. Neuroprotective effects of theanine and its preventive effects on cognitive dysfunction. Pharmacol Res. 2011 Aug;64(2):162-8.
  40. Korner E, et al. Sleep-inducing effect of L-tryptophane. Eur Neurol 1986;25 Suppl 2:75-81
  41. Higgins JP and Flicker L. Lecithin for dementia and cognitive impairment. Cochrane Database Syst Rev. 2003;(3):CD001015
  42. Kennedy DO, et al. Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm). Psychosom Med. 2004 Jul-Aug;66(4):607-13
  43. Mori K, et al. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009 Mar;23(3):367-72. doi: 10.1002/ptr.2634.
  44. Lee YK, et al. Protective Effect of the Ethanol Extract of Magnolia Officinalisand 4-O-Methylhonokiol on Scopolamine-Induced Memory Impairment and the Inhibition of Acetylcholinesterase Activity. Journal of Natural Medicines 3 (2009): 274–282. PMC. Web. 8 Aug. 2015
  45. Reger MA et al. Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging. 2004 Mar;25(3):311-4
  46. Forsyth LM, et al. Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome. Ann Allergy Asthma Immunol. 1992; 82(2):186-91
  47. Narahashi T, et al. Unique mechanism of action of Alzheimer's drugs on brain nicotinic acetylcholine receptors and NMDA receptors. Life Sci. 2003 Dec 5;74(2-3):281-91.
  48. Rusted JM and Trawley S. Comparable effects of nicotine in smokers and nonsmokers on a prospective memory task. Neuropsychopharmacology. 2006 Jul;31(7):1545-9
  49. Ostrovskaia RU, et al. The original novel nootropic and neuroprotective agent noopept. Eksperimental’naia i klinicheskaia farmakologiia. 2002;65:66-72
  50. Dimpfel W, Storni C, Verbruggen M. Ingested oat herb extract (Avena sativa) changes EEG spectral frequencies in healthy subjects. J Altern Complement Med. 2011 May;17(5):427-34. doi: 10.1089/acm.2010.0143. Epub 2011 May 12
  51. Bottini G, et al. Oxiracetam in dementia: a double-blind, placebo-controlled study. Acta neurologica Scandinavica. 1992;86:237-41
  52. Akhondzadeh S, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. Journal of Clinical Pharmacy and Therapeutics 2001, 26(5):363-367
  53. Tiurenkov IN, et al. Fenibut and its citrate prevent psychoneurological disorders caused by chronic stress (paradoxical sleep deprivation). Eksp Klin Farmakol. 2012;75(6):8-13
  54. Bobkov Iu G, Morozov IS, Glozman OM, Nerobkova LN and Zhmurenko LA. Pharmacological characteristics of a new phenyl analog of piracetam–4-phenylpiracetam. Biulleten’ eksperimental’noi biologii i meditsiny. 1983;95:50-3)
  55. Ladd, Sandra L, et al. Effect of phosphatidylcholine on explicit memory. Clinical Neuropharmacology, Vol 16(6), Dec 1993, 540-549
  56. Phosphatidylserine (PS) – multitasking phospholipid that helps build, power and protect brain cells; best evidence-backed nootropic for memory13
  57. Kato-Kataoka A et al. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr. 2010 Nov;47(3):246-55
  58. Kopelevich VM. Synthesis and study of psychotropic and hypotensive properties of new picamilon derivatives. Search for New Drugs. Pharmaceutical Chemistry Journal. October 1997, Volume 31, Issue 10, pp 536-539.
  59. Devaraja, S, et al. Supplementation with a Pine Bark Extract Rich in Polyphenols Increases Plasma Antioxidant Capacity and Alters the Plasma Lipoprotein Profile. Lipids, Vol. 37, no. 10 (2002)
  60. Winblad B. Piracetam: a review of pharmacological properties and clinical uses. CNS drug reviews. 2005;11:169-82
  61. Dinan TG, Stanton C, Cryan JF. Psychobiotics: a novel class of psychotropic. Biol Psychiatry. 2013 Nov 15;74(10):720-6
  62. McLean A, Jr., Cardenas DD, Burgess D and Gamzu E. Placebo-controlled study of pramiracetam in young males with memory and cognitive problems resulting from head injury and anoxia. Brain injury. 1991;5:375-80
  63. Zhou Y, et al. Orally administrated pterostilbene attenuates acute cerebral ischemia-reperfusion injury in a dose- and time-dependent manner in mice. Pharmacol Biochem Behav. 2015 Aug;135:199-209
  64. Kim, J, et al. Pyrroloquinoline quinone inhibits the fibrillation of amyloid proteins. Prion. 2010 Jan-Mar;4(1):26-31
  65. Veronica Witte, et al. Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults. Journal of Neuroscience 34.23 (2014): 7862-870
  66. Darbinyan V, Kteyan A, Panossian A, et al. Rhodiola rosea in stress induced fatigue – a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine 2000;7:365-371
  67. Habtemariam S. The Therapeutic Potential of Rosemary (Rosmarinus officinalis) Diterpenes for Alzheimer’s Disease. Evid Based Complement Alternat Med. 2016; 2016: 2680409
  68. Rosenbaum JF, et al. The antidepressant potential of oral S-adenosyl-l-methionine. Acta Psychiatr Scand. 1990 May;81(5):432-6
  69. Sowndhararajan K, et al. An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis. Biomed Pharmacother. 2018 Jan;97:958-968.
  70. Fava M, et al. A Double-blind, Randomized Trial of St John’s Wort, Fluoxetine, and Placebo in Major Depressive Disorder. Journal of Clinical Psychopharmacology. Oct 2005. Vol. 25, Issue 5;441-447
  71. Tiev KP et al. Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placebo. Rev Med Interne. 1999 Oct;20(10):912-8
  72. Kong WX, et al. Effects of taurine on rat behaviors in three anxiety models. Pharmacol Biochem Behav. 2006 Feb;83(2):271-6
  73. Franco R et al. The relevance of theobromine for the beneficial effects of cocoa consumption. Front Pharmacol. 2015; 6: 30
  74. Cox KHM, Pipingas A, Scholey AB. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol October 2, 2014
  75. Mahoney CR, et al. Tyrosine supplementation mitigates working memory decrements during cold exposure. Physiol Behav. 2007 Nov 23;92(4):575-82. Epub 2007 May 22
  76. van Groeningen CJ, et al. Clinical and pharmacologic study of orally administered uridine. J Natl Cancer Inst. 1991 Mar 20;83(6):437-41
  77. Fernandez S, et al. Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis. Pharmacol Biochem Behav. 2004 Feb;77(2):399-404
  78. Subhan Z, Hindmarch I. Psychopharmacological effects of vinpocetine in normal healthy volunteers. Eur J Clin Pharmacol. 1985;28(5):567-71
  79. Butterworth RF. Thiamin deficiency and brain disorders. Nutr Res Rev. 2003 Dec;16(2):277-84.
  80. Haslam RH, Dalby JT, Rademaker AW. Effects of megavitamin therapy on children with attention deficit disorders. Pediatrics 1984;74:103-11
  81. Deijen JB, van der Beek EJ, Orlebeke JF, van den Berg H. Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort. Psychopharmacology. 1992;109(4):489–496
  82. Palatnik A, et al. Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. J Clin Psychopharmacol. 2001 Junl21(3):335-9
  83. Smith AD, Refsum H. Homocysteine, B Vitamins, and Cognitive Impairment. Annu Rev Nutr. 2016 Jul 17;36:211-39
  84. Murakami K, et al. Dietary intake of folate, other B vitamins, and omega-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults. Nutrition. 2008 Feb;24(2):140-7.
  85. Prediger RD et al. Effects of acute administration of the hydroalcoholic extract of mate tea leaves (Ilex paraguariensis) in animal models of learning and memory. J Ethnopharmacol. 2008 Dec 8;120(3):465-73.

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