Want to learn about the best brain supplements? You’ve come to the right place. In this article, we will cover everything you need to know about today’s leading formulas for nourishing the brain.
We will be discussing what these dietary supplements are, why people use them, and how they are believed to work. We'll also highlight some of the scientific evidence behind brain supplements. Finally, we will reveal the best stack supplements that skillfully combine nutrients to maximize overall brain health. Let’s get to it.
What are brain supplements?
So what are brain supplements? Simply put, brain supplements are over-the-counter formulas in the nutritional supplement category designed to support healthy brain function. A brain supplement (also known as a brain pill) can take many forms. Some examples:
Vitamins and minerals found in a high quality multivitamin supplement may be considered brain supplements. In fact, these essential nutrients are an important foundation for brain health, but many people fail to get enough.
Herbs, including from traditional Chinese and Ayurvedic wellness, are brain supplements. One class of herbs, adaptogens, regulates stress responses, which may have far-reaching effects on brain function. Ginkgo biloba is one famous brain herb, but there are many more.
Omega-3 fatty acids and other healthy fats, whether sourced from fish, krill, or algae, are considered as brain supplements too. Also, coconut oil supplies healthy MCT fats that help to fuel and optimize brain cell energy production.
Antioxidants are important contributors to brain wellness, especially in the context of fighting cognitive decline related to brain aging. They help by fighting free radicals, which are unstable molecules that damage brain cells (and other cells throughout the body).
Amino acids may often be associated with sports nutrition, but they are also crucial for the brain. Amino acid nutrients play a role in forming the brain chemicals that drive mental performance, and can help to restore a brain that is depleted by stress and multitasking.
Brain supplements vs. Nootropics vs. Smart Drugs
These three terms are sometimes used interchangeably. But they are not quite the same. Brain supplements and nootropics are in the same category, with a slightly different emphasis.
Smart drugs, however are a different category altogether. While there are no official definitions, for the purpose of this article, here are some distinctions to keep in mind.
Brain supplements: This is the first category to arrive on the dietary supplement market. It focuses on brain health, especially in the context of longer-range wellness. For example, brain supplements may slow cognitive decline or help with memory issues. But because a healthy brain functions optimally, they also help with overall cognition.
Nootropics: A newer subset of brain pills, nootropics are more associated with brain performance. Their intended uses tend to emphasize active, dynamic cognition, such as in academic, professional and competitive settings.
Smart drugs: Supplements and drugs are not the same. Smart drugs are pharmaceuticals that must be prescribed by a doctor and taken under a doctor’s supervision. Because this article is about dietary supplements, we will not be discussing smart drugs.
Brain supplements are well-rounded. They support the brain's structures and functions, nourishing it for healthy performance.
How do brain supplements work?
Brain nutrients can have one or more biological actions that help. Some of these actions include:
- Maintaining plasticity, which refers to new connections in the brain
- Supporting neurogenesis: the creation of healthy new brain cells
- “Fertilizing” the brain to nourish new brain cells and new connections
- Enhancing brain energy to better power cognition, maintenance and regeneration
- Protecting healthy brain structure against irregular changes
- Maintaining healthy levels of neurotransmitters for attention, memory, mood, focus, etc.
- Promoting blood flow to the brain that delivers energizing oxygen and nourishment
- Defending neurons from destructive free radicals that accelerate cell aging
All these bio-activities combine to improve brain function.
What are the benefits of brain supplements?
There are at least 80 individual nutrients that may be considered brain supplements. They influence dozens of different biological pathways, both in the brain and in other parts of the body that affect brain performance.
There are many benefits to cover, including popular uses, anecdotal reports, and results from well-designed human research trials. But for now, let’s talk about the primary benefits many people are seeking when they take dietary supplements for the brain.
Brain health is among the most evidence-backed applications for brain pills. Historically, mature adult populations primarily took these supplements for long-range brain health benefits.
But people of all walks of life are increasingly looking for brain health support. In part for health, but also because a healthy brain simply performs better. For this reasons, many brain nutrients that support optimal brain health have also been shown to improve cognitive functioning.
Age-associated memory impairment, which is common in later years, may be the first real symptom that compels people to seek out brain supplements. Forgetfulness, misremembering names, struggling to find the right words – these occasional cognitive challenges can be addressed with the best brain supplements, especially if they are targeted memory pills.
As we grow older, memory becomes more important. However, memory is increasingly recognized for its role in more dynamic and performance-driven activities. As a result, younger populations are now seeking more versatile memory supplements that help with long-range memory, short-term and working memory, recall, learning, studying and more.
Some brain supplements for age-related memory decline are also effective at boosting performance-driven memory.
Brain fog refers to muddy thinking, sluggish mental processing, and a general lack of mental clarity. These symptoms may be associated with aging, including menopause. Mental fog can also be a result of stress, burnout, overworking, studying too hard, lifestyle choices and other issues.
Increasingly, people are seeking out brain supplements as a safe and natural way to restore brain power, clear the mental fog and improve brain function in day-to-day living.
Nootropic supplements for performance may also be designed to clear brain fog, especially in the context of hard-working professionals experiencing burnout.
Attention, focus and concentration
Looking for a mental edge? If so, you may want more dynamic effects from your brain supplement, including support for attention, focus, concentration and mental clarity.
Brain supplements that help these cognitive functions may present a viable alternative to smart drugs, stimulants and their potential side effects.
Brain pills instead may help with mental acuity and clarity by influencing neurotransmitters, ramping up brain energy, countering the effects of stress and more.
Mental health is a key contributor to overall cognitive function. Some supplements for the brain may help with mood-related aspects of mental health, such as anxiety, depression, and stress. By helping to promote a positive, balanced mindset, these nutrients can improve cognitive function in day-to-day life, as well as improving overall quality of life.
Mental Energy and Motivation
Other brain supplement ingredients may help mental health by powering-up the brain's energy metabolism and neurotransmitters that are involved with motivation and reward. Mental energy is a performance-oriented nootropic benefit.
Brain pills and nootropic supplements that boost mental energy may revitalize day-to-day performance without the use of stimulants. Nootropic supplements may focus on brain power as a competitive cognitive edge. However, a brain pill might focus more on brain energy as an important contributor to long-range healthy cognition.
What Ingredients Look for in a Top Brain Supplement For Adults
Ready to buy a brain supplement? You have many options.
Stack brain supplements combine several nutrients into one capsule. They are convenient and cost-effective, but require expert formulation due to the possible interactions (both positive and negative) between many ingredients.
Single-ingredient supplements are also available. They can supply larger doses because they don't have to share capsule space. But buying multiple bottles can be expensive. Taking only one brain supplement also means you don't get possible brain-boosting synergies that can be achieved with a smart stack.
First, we will discuss some of the best single ingredients in this class of cognitive supplements.
Next we will cover the most effective brain pill stack supplement, that combines 11 ingredients into 1 formula.
And finally, we'll highlight a single-ingredient supplement and a "short stack" with 4 ingredients, giving you more brain supplement options to choose from.
Some top brain nutrients to consider include the following:
Citicoline (CDP Choline)
Citicoline may be the single best ingredient to look for in a dietary supplement for the brain. That's because it combines bioactivities that help improve cognitive function and support overall brain wellness. Citicoline benefits have been linked to better cognitive energy, memory, attention and brain health.
This brain pill is believed to work via a few different mechanisms. Notably, it appears to boost brain energy. It also plays a role in optimizing brain cell membranes and regulating neurotransmitters.
Citicoline may be a good choice for supporting brain health, especially brain regeneration, because it helps increase both the raw materials and energy that are required for brain cell regeneration, maintenance and repair.
Research suggests citicoline may rejuvenate the brain.
In this study, citicoline supplements supplying the patented Cognizin form were found to significantly improve brain functions that are important for brain regeneration. Specifically, the Cognizin was linked to a 14% increase in brain energy and 26% faster brain cell membrane turnover (linked to brain repair, maintenance and regeneration).
PS is a healthy fat that is concentrated in the brain. Like citicoline, it is a multitasker. It plays a role in brain energy, helps promote nerve growth factor (NGF), regulates neurotransmitters and serves as a raw material for forming brain cell membranes.
Phosphatidylserine (PS) has been linked to several cognitive benefits, including for concentration, language, attention, mood and more.
Of all the brain supplements, PS is the best to boost memory.
It may in fact be the most science-backed nutrient for memory. PS has been widely researched for assisting with memory loss and degenerative brain concerns. It was also the first brain pill with enough credible evidence to make a qualified claim for helping with Alzheimer's disease, improving memory loss and preventing cognitive decline.
Phosphatidylserine (PS) has been shown in clinical trials to boost memory in several ways. Researchers have suggested it may help with:
Formation of short-term memory
Consolidation of long-term memory
Ability to create new memories
Memory retention support
Ability to retrieve memories
In one study, researchers reported that PS 100 mg daily – taken by 51 patients between the ages of 55-75 for a span of twelve weeks -- appeared to be associated with improvements in multiple aspects of cognitive performance, including memory. Researchers concluded that PS improved brain function and seems to hold potential for helping with early age-related cognitive issues.
Phosphatidylserine is equally exciting for its nootropic benefits. It helps maintain mental clarity, supports language, assists with stress and has even been researched as a supplement to improve sports performance (golf, specifically).
L-Tyrosine is an amino acid that serves as a "master precursor" to several cognitive performance brain chemicals.
Under high-intensity thinking, stress and distracting conditions, key brain chemicals are depleted. Supplementing with L-Tyrosine seems to help.
It has been shown in research to improve several cognitive functions in stressful scenarios, including while sleep-deprived, multitasking, and being exposed to loud noises and cold water.
L-Tyrosine has also been linked to better mood, concentration and overall mental performance. It's a great ingredient to look for if you need help with dynamic brain power.
In one study, subjects were given the either a placebo pill or L-Tyrosine at a dosage of 150 mg per kilogram of bodyweight one hour prior to performing a series of tests related to cognitive performance and memory function. The researchers reported that L-Tyrosine supplementation appeared to maintain working memory function under demanding multitasking conditions that would usually degrade mental performance.
Pine Bark Extract
Pine Bark Extract (PBE) supplies a powerful complex of antioxidants called proanthocyanidins that protect healthy brain cells. Its antioxidant complex is suggested to be 20 times more powerful than vitamin C. Pine Bark's neuroprotective potential that makes it a strong ingredient for any cognitive health supplement.
Pine bark extract is also a nitric oxide stimulator. Nitric oxide (NO) causes blood vessels to relax, which helps to encourage robust blood flow to the brain. Enhanced blood flow nourishes the brain with oxygen and glucose, helping it to perform better. PBE has also been suggested to support brain regeneration, which further promotes overall brain health.
Did you know? When shopping for a brain pill with pine bark extract, be sure to look for one that is standardized for proanthocyanidins. These are the active ingredients that make pine bark extract effective. Standardization is a process that calibrates supplements to a precise level of active ingredient. Pine bark extract standardized to 95% proanthocyanidins is the strongest form that is available on the market today.
L-Theanine is an amino acid found in green tea. It is unique among brain boosters because it works by influencing brain waves. Specifically, it raises the Alpha brain waves that are associated with relaxed mental alertness.
L-Theanine has been shown to promote attention while reducing stress difficult mental tasks. It also potentiates caffeine while reducing its jittery side effects. This is part of the reason why green tea, as a natural stimulant, feels gentler than coffee stimulation.
Green tea is linked with sharper cognitive function later in life; a benefit that researchers have linked to L-Theanine's neuroprotective effects.
In one randomized, placebo-controlled, double-blind study, subjects between the ages of 50 and 69 were given L-Theanine as a single dose and as a 12-week course of daily supplementation, and then tested for cognitive abilities. Researchers revealed that a single dose of L-Theanine appeared to effectively boost brain function. They suggested it may contribute to improving attention, working memory and executive functions.
Bacopa monnieri is an herb found in brain supplements that is highly regarded for its memory benefits. Bacopa appears to have several beneficial bioactivities for the brain, including support for antioxidant brain protection and blood flow to the brain.
Bacopa is versatile, but may be most well-known for helping with studying and new learning.
This is due to its ability to support memory and memory retention, including one intriguing study that showed bacopa appeared to slow down the rate of forgetting newly-acquired information.
In the study, healthy volunteers took either a placebo or Bacopa 300 mg every day for 12 weeks, completing mental performance tests at the five-week mark and end point. Researchers associated Bacopa with improvements across multiple aspects of cognitive performance. Researchers summed up these effects by suggesting Bacopa may “improve higher order cognitive processes”, which involve acquiring and processing new information into learning and memories.
Beyond its memory retention reputation, Bacopa monnieri is considered an herbal adaptogen. That means it possesses anti-stress activity, as well as helping to keep the body in an overall healthy state of balance.
Omega 3 fatty acids
Omega 3 fatty acids, especially DHA, help to support brain health. But according to a national nutritional intake survey, most Americans fail to get enough Omega-3 fatty acids. This may be partly because fatty fish, which are rich in Omega-3s, are not consumed with regularity in most American diets.
DHA is a necessary nutrient for healthy brain cell development in the womb and early childhood. It is, in fact, the most important Omega-3 fatty acid for the brain. DHA is also required for healthy development of the eyes and entire central nervous system.
Researchers have linked Omega-3 DHA intake to improvements in attention, memory, mental flexibility, mood and overall brain wellness.
The B-vitamins are a group of eight water-soluble vitamins that are widely recognized for their role in energy, neurotransmitters and myelin sheath production.
Cognitive symptoms of deficiency in the B-vitamins include brain fog, stress, fatigue, and confusion. Vitamin B12, specifically, has been linked in research to impaired cognition and memory in older adults. Restoring suboptimal B-complex intake with a nutritional supplement
Vitamins B6, B9 and B12 are especially important for reducing homocysteine levels.
High homocysteine interferes with blood flow to the brain, and has been implicated in cognitive decline, along with cardiovascular health. The good news is, although homocysteine is a risk factor for several health concerns, it is modifiable. And vitamins B6, B9, and B12 appear to be effective for just that.
One meta-analysis of 12 clinical trials with a total of 1114 study subjects, researchers found that dietary folic acid (B9) was associated with a 25% reduction in blood homocysteine levels. Researchers reported that adding Vitamin B12 was associated with an additional 7% reduction in blood homocysteine levels. Researchers concluded that supplementing with 0.5 to 5 mg folic acid and about 0.5 mg vitamin B12 could be expected to reduce blood homocysteine levels by about a quarter to one-third.
Lion’s Mane (Hericium erinaceus) is an edible Chinese mushroom. Among nootropic supplements, Lion's Mane Mushroom is prized for its ability to boost Nerve Growth Factor (NGF). NGF promotes the genesis, survival and growth of neurons (brain cells); as well as helping with synthesis of the fatty myelin sheath that surrounds and protects neurons.
Research suggests that Lion's Mane may help support a bright mood and balanced emotions. It may also be present in some memory pills because it has shown some potential in human clinical research to help with mild age-related cognitive issues.
In one double-blind, placebo-controlled clinical trial, subjects in the 50-80 age group took Lion’s Mane Mushroom or placebo three times a day for 16 weeks. Researchers found that the Lion’s Mane supplementation was associated with enhanced cognitive performance scores, and that cognitive testing scores dropped four weeks after supplementation ceased. The researchers concluded that Lion’s Mane Mushroom may be a helpful therapy in cases of mild cognitive impairment.
Rhodiola rosea is known for its golden root, an herb that has long been prized for its revitalizing properties. A legendary adaptogen and potent brain booster, it blunts stress hormones to strengthen mental and physical performance under pressure. Rhodiola rosea has also been suggested to help concentration, energy, physical intensity, mood and work capacity.
Rhodiola's active salidroside, has been suggested to help with brain degeneration in animal research.
In one animal study researchers noted that irregular proteins in mice were tied to learning problems, memory problems, and brain inflammation and oxidative stress – but that salidroside supplementation appeared to reverse these negative changes to the brain, suggesting a protective effect against brain degeneration.
In a human clinical trial, Rhodiola rosea demonstrated its adaptogen properties as a cognitive benefit. In this study, researchers gave Rhodiola rosea to a group of 56 doctors who were starting a night shift. Researchers then tested the doctors for performance across various cognitive functions. At the study's conclusion, researchers suggested that Rhodiola rosea appeared to reduce general fatigue under stressful conditions.
Acetyl L-Carnitine (ALCAR)
ALCAR is an amino acid that is sometimes used in dietary supplements for the brain. It is primarily known for its ability to promote the brain chemical acetylcholine, which is involved in memory, mental clarity and overall brain wellness.
ALCAR also functions as a "shuttle" for cells' mitochondria power plants. It funnels in fuel to be incinerated, while also helping to remove toxins from mitochondria.
Acetyl L-Carnitine is used in sports nutrition and nootropic supplements, but has also shown promise as an ingredient to improve brain health over the long haul.
In a research review that analyzed 21 different clinical trials, authors reported that Acetyl-L-Carnitine is not only well-tolerated, but also appears to improve mild cognitive impairment, and may even help to ward off brain deterioration.
PQQ (Pyrroloquinoline Quinone)
PQQ is a nutrient similar to the B-vitamins. It is a good ingredient for brain supplements due to its ability to both energize and protect brain cells. Researchers have suggested PQQ appears to influence cells' powerplants, which are called mitochondria.
Specifically, researchers have reported PQQ may protect mitochondria, enhance their activity, and help increase their numbers within brain cells, and cells throughout the human body. It is also a potent antioxidant that helps to protect brain cells' membranes.
In one human study, 71 healthy adults were given PQQ, PQQ + CoQ10, or placebo every day for 12 weeks. At the study's conclusion, researchers reported that PQQ appeared to improve cognitive function related to higher-order processing, including attention and working memory. Researchers also reported that combining PQQ with another brain supplement, CoQ10, appeared to produce greater improvements in cognitive function.
Now, let's take a look at the industry-leading supplements that supply all these nootropics and stack together seamlessly for a powerful boost.
Best Brain Supplements for Adults
Mind Lab Pro®
If you were to buy one brain supplement, Mind Lab Pro® is the one you want. It is a single nootropic stack that supplies many of the best brain supplement ingredients that we've discussed in this article.
Mind Lab Pro® is expertly formulated to provide far-reaching brain support. By optimizing several brain pathways at once, it is uniquely capable of boosting both short-term mental performance and long-range brain wellness.
Mind Lab Pro nourishes for health, and boosts for performance. Making it the ultimate brain supplement.
Some examples of Mind Lab Pro's benefits for various cognitive abilities:
- Fluid verbal skills and language ability
- Improved attention span and concentration
- Enhanced memory, including long-range & recall
- Revitalize without stimulants; fight mental fatigue
- Maintains mental clarity, helps with brain fog and mental fatigue
- Help for studying, learning, test-taking
- Supporting mood balance; fighting stress
Some long-range Mind Lab Pro® benefits that improve long-range brain outlook:
- Helps ease symptoms of mild age-related decline
- Maintains healthy memory function when taken over time
- Protects brain cells by reinforcing antioxidant defenses
- Helps to maintain normal brain structure
- Nourishes brain repair and regeneration
Mind Lab Pro® optimizes all of the potential brain benefits discussed in this article by using 11 brain pill ingredients. All of which have been shown to be safe and effective.
Highest Quality brain supplement
Your brain deserves the best. When it comes to brain pills, it doesn't make sense to skimp on quality. The brain is far too important to be fed inferior ingredients and low-quality formulas. Mind Lab Pro® is the highest quality product of its kind. It uses premium ingredients, and delivers them in advanced vegan NutriCaps, which are infused with prebiotics to help assist with digestion.
Mind Lab Pro itself has been shown to be safe and effective.
Of all the high quality brain supplements on the market, Mind Lab Pro is one of the only ones to have undergone rigorous scientific research. A human clinical trial on Mind Lab Pro's effects has been completed, with promising results to be published in the near future.
Alongside Mind Lab Pro®, here are some other Best Brain Supplements for Adults:
Performance Lab® Mind
Performance Lab® Mind is another brain stack. But unlike other nootropic supplements, it has a unique design that encourages faster recovery from intense mental exertion.
Combining four brain nutrients, Performance Lab® Mind enhances cognitive functions like focus, speed, energy, memory, motivation, and more. As a bonus, its ingredients also support the brain over time.
Performance Lab® Mind features Cognizin® citicoline, Sharp-PS® Green (plant-based phosphatidylserine), Pine Bark Extract (95% proanthocyanidins) and Ajipure® L-Tyrosine. Its key cognitive benefits include:
- Supports focus, memory, motivation, mood, multitasking, and more
- Promotes peak mental performance in high-pressure environments
- Restores neurotransmitters for healthier, sharper bounce back from mental exertion
- Helps optimize brain cell membranes for efficient function and long-range health
- Stim-free mental energy for a clean cognitive lift with no crash
Like Mind Lab Pro®, Performance Lab® Mind is a sort of brain pill/nootropic hybrid. They both help to improve brain function in many ways, but not at the expense of health... rather, in support of cognitive health.
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Performance Lab® MCT
Sourced from coconuts, medium-chain triglycerides (MCTs) are brain healthy fats that convert in the body to ketones, an "alternative energy" source for fueling the brain.
Performance Lab® MCT Oil supplies medium-chain triglycerides Caprylic Acid (C8) and Capric Acid (C10) sourced from 100% Organic, Non-GMO Coconuts. Not all MCT oils are clean, but this one is: It is produce with hexane-free technology and 3x distilled for purity.
Some cognitive benefits associated with Performance Lab® MCT Oil:
- Helps to fuel the brain quickly and efficiently
- Supports vitality in both body and mind
- A way to raise energy during intense exercise
- Fights brain fog during ketosis and intermittent fasting
- Sim-free energy: Instead boosts cells powerhouse mitochondria in the brain and throughout the human body
- Supports appetite control
C8+C10 MCTs fuel cognitive function fast. They are efficiently absorbed and delivered to the brain. MCTs can also help to protect brain cells' mitochondria, for longer-range brain results.
Did you know? The brain supplement Phosphatidylserine, found in Mind Lab Pro, absorbs more efficiently when it is taken with a fat. Performance Lab MCT supplies a healthy source of fats that can help with PS absorption.
Among nootropic supplements, MCT oil is a little different: It can be added to coffee, shakes and smoothies; used in cooking; or even consumed straight. Powder MCT nootropic supplements are also available, and sometimes are presented in capsule form or as a coffee creamer. This makes MCT easy to incorporate into your healthy lifestyle, especially if you are on a Keto diet, exercising or intermittent fasting.
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Performance Lab® Energy
Cell energy is key for cognition and overall brain wellness. Performance Lab® Energy is an innovative stim-free energy supplement that's uniquely qualified to power-up the brain and boost cognitive function. It works primarily by boosting cells' powerplant mitochondria. Which happen to be highly concentrated in your gray matter.
Performance Lab® Energy supplies several nootropics/ cell energizer hybrid ingredients. Its black pepper extract is a metabolism booster that improves absorption of nutrients, including CoQ10, which is also in the formula.
The full ingredient lineup: MicroActive® Q10 (CoQ10), BioPQQ® (Pyrroloquinoline Quinone), Acetyl-L-Carnitine (ALCAR), BioPerine® Black Pepper Extract, Bio-Enhanced® R-Lipoic Acid.
Some cognitive benefits associated with Performance Lab® Energy:
Optimizes the mitochondria that power the brain and all cells in the body
Raises energy without stimulants and their related jitters, side effects and crashes
Enhances mental vitality, as well as physical vitality. Great for exercise.
The most sophisticated stim-free energy booster ever developed, Performance Lab® Energy is a must-have supplement for a supercharged brain supplement regimen.
Because the brain is infinitely complex, there is no single approach to totally boost brain health and performance. This is why brain health supplements have taken to “stacking” multiple brain nutrients, each that targets a specific brain bio-pathway or bio-activity. When the combination is just right, you can unlock both healthy brain function and peak brain performance.
Mind Lab Pro® is today's best brain supplement in part due to its stacking strategy. It combines so many brain nutrients so effectively, that no other product on the market can approach its depth and breadth of brain benefits. With an innovative formula designed to optimize multiple cognitive pathways at once, Mind Lab Pro® functions as an unparalleled whole-brain optimizer.
Mind Lab Pro® Universal Nootropic™ design unlocks full-spectrum benefits for short-term cognition and long-range brain health.
Supporting far-reaching benefits for focus, learning, memory, relaxation, stress resistance, brain health and more, Mind Lab Pro® is a great all-purpose formula that can help pretty much anyone. But if you want a little extra boost of some brain benefits, you can add on our other recommended products Performance Lab® Mind, MCT and Energy. These supplements match Mind Lab Pro quality, and combine effectively with its advanced formula design.
To get the best deal on Mind Lab Pro®, click here.
To get the best deal on Performance Lab® Mind, click here.
To get the best deal on Performance Lab® MCT, click here
To get the best deal on Performance Lab® Energy, click here.