For many men, “nootropics” (cognitive enhancer dietary supplements) aren’t about chasing a buzz—they’re about boosting performance. Whether it’s staying focused at work, showing up strong in training, or keeping your mind sharp as you age, cognitive edge has become part of modern masculinity.
According to CDC NHANES data, 67.3% of men age 60+ reported using a dietary supplement in the past 30 days.(1) And according to a Harvard study, about 1 in 4 adults over age 50 take at least one supplement for brain health, specifically. Dietary supplements and cognitive function are converging in adults, and performance-driven men are a big reason why.
If you clicked this article, you’re probably looking for a practical answer: which nootropics make the most sense for men—for focus, mental stamina, memory, mood, motivation, training goals and overall cognitive edge—without turning into a jittery, overstimulated mess.
Below, we’ll break down why men often seek nootropics, which evidence-backed ingredients tend to fit “male performance” goals, and why an all-in-one stack like Mind Lab Pro® is often the most complete and convenient option. Let's get to it!
Key Takeaways
- Nootropics, also called cognitive enhancers or "smart drugs," are dietary supplements used to boost various brain functions and overall brain health.
- Nootropics covered in this guide: Citicoline (CDP-choline), phosphatidylserine, bacopa monnieri, lion’s mane, maritime pine bark extract, N-acetyl L-tyrosine, L-theanine, rhodiola rosea, omega-3 fatty acids, plus supportive B-vitamins (B6, folate, B12) and optional caffeine stacking.
- Men often use nootropics for work performance (thinking skills like focus, mental stamina, motivation), training support (stress tolerance, fatigue resistance), and healthy aging (memory, clarity, support brain health over time).
- The best “male-friendly” nootropics tend to target a few pillars: brain energy + drive, stress resilience, memory/learning, and calm focus (so you stay sharp without feeling wired).
- L-theanine is especially useful for men who use caffeine for work or the gym: it’s widely used to support a smoother, calmer form of focus—and it pairs well with coffee or tea.
- Start simple: pick 1–2 goals (focus/drive, stress, memory, or calm energy), start low, track your response for 2–4 weeks, then adjust.
- In this article, we recommend top nootropic products for men including Mind Lab Pro®, Pre Lab Pro®, Performance Lab® Omega-3, and Performance Lab® NutriGenesis® Multi for Men.
Disclaimer
This article is for educational purposes only and is not medical advice. Always consult a qualified healthcare professional before using any nootropic or dietary supplement—especially if you have a medical condition, take prescription medications, have a history of high blood pressure, psychiatric disorders, anxiety, sleep problems, or heart rhythm issues, or if you are planning surgery. Supplements are not drugs like prescription stimulants or other prescription nootropics. Supplements are not intended to diagnose, treat, cure, or prevent any disease, including cognitive concerns like Alzheimer's disease. Use supplements only under a doctor’s guidance to ensure clinically relevant doses and monitor potential side effects.
Why Do Men Take Nootropics?
Nootropics, sometimes called cognitive enhancers or "smart drugs," are supplements used to support brain performance—things like focus, attention, memory, motivation, mood, and mental stamina.
For men, the appeal is often straightforward: you want your brain to perform at its peak—clear, decisive, consistent—even when life is demanding. The best nootropics for men typically support the same “masculine performance” pillars that show up in real life: drive, calm under pressure, and the ability to keep learning and executing over time.
So what are men looking for in terms of nootropic benefits?
Focus, drive, and “mental stamina”
A lot of men don’t just want “focus”—they want output. That usually means better attention control, steadier energy, less stress-reactivity, and fewer mental crashes. This is one reason adaptogens and calming-focus ingredients are so popular in men’s stacks: they can help you stay productive under pressure without needing more and more stimulation.
Athletic performance (intensity, reaction time, and “game-day focus”)
Physical training results depend on mental drive, pain tolerance, consistency, reaction time, and the ability to stay composed when the body is under strain. That’s why men often look for nootropics that support “calm aggression”: steady energy, sharper focus, and better stress tolerance without over-stimulation. Whether it’s lifting, combat sports, endurance exercise, or motivation, the right nootropics support the mental side of athletics.
Professional performance (focus, output, work under pressure)
Men frequently seek nootropics because work demands can be relentless: long hours, high stakes, constant digital distraction, and the expectation to stay confident and competent no matter what’s happening internally. The right nootropic ingredient or stack supports productivity. Nootropics that support attention control, mental stamina, stress resilience, and a steadier mood can help men with sharper meetings, cleaner communication, stronger follow-through, and less cognitive fatigue at the end of the day.
Mood, composure, and stress resilience
A lot of men are intent on composure: the ability to stay grounded, emotionally steady, and clear-headed under pressure. Chronic stress life symptoms can quietly erode masculine energy—sleep gets worse, motivation drops, focus becomes unreliable, and confidence can take a hit. That’s why many men gravitate toward nootropics known for calm focus and improving resilience to life stress symptoms like brain fog and burnout. The goal: feel more in control of your mind, less reactive, and more capable of showing up strong.
Low Testosterone-related brain fog
Men often notice that human cognition shifts with age; this may be attributed to a natural decline in testosterone. While “low T” is not the only factor (sleep, stress, metabolic health, and workload matter a lot), many men start looking for nootropics in their 40s, 50s, and beyond because they want to reclaim more youthful brainpower: clear thinking, reliable recall, and the ability to stay sharp without feeling run down.
Men 50+: protecting memory and brain health (not just “performance”)
In midlife and later years, men often shift from short-term performance to a longer-term goal: brain health. That changes the strategy. Instead of chasing a quick buzz of cognitive enhancement, men tend to do better with stacks with cognitive health support for memory, stress resilience, and foundational brain nutrition—so performance stays steady and sustainable. Read more: safe & effective nootropics for long-term use
Best Nootropics for Men in 2026
Below are evidence-backed nootropics that tend to map well to men’s goals—especially ingredients found in Mind Lab Pro®. For each, you’ll get a quick origin story, the most “male-relevant” benefits for overall cognitive function, and a study highlight.
Citicoline (Cognizin®, CDP-Choline)
Citicoline (CDP-choline) is one of the most respected “core” nootropics because it supports brain performance from two angles at once: it provides choline for acetylcholine pathways (one of the key neurotransmitter systems tied to learning, attention, and memory), and it supports the phospholipids that help maintain healthy brain cell membranes.
It is often described as “clean mental fuel” or "focused energy." Research seems to back this up: The patented Cognizin® form has been shown to increase brain energy metabolism by 13.6%.(2) In a randomized, double-blind, placebo-controlled trial in healthy older adults with age-associated memory impairment, citicoline supplementation improved overall memory performance—particularly episodic memory—versus placebo.(3)
For men, this aligns perfectly with a real-world goal: staying mentally fast and clear in the present day and as the years add up. It also fits the professional-performance mindset: citicoline is widely used by high achievers because it tends to support output and mental stamina without the jittery, anxious edge that can come with heavier stimulants.
Phosphatidylserine (PS)
Phosphatidylserine (PS) is a phospholipid natural nootropic found in brain cell membranes and is widely used for stress resilience—especially when training hard, working long hours, or running on limited recovery. In the nootropics world, PS is famously known as a top nootropic for memory.
PS improves memory, but is also known as a “resilience” ingredient: it’s widely used to support a steadier stress response, clearer thinking under pressure, and a calmer, more composed baseline—especially when you’re training hard, working long hours, stacking responsibilities, or running on limited recovery. That reputation has real support in human research.
In a placebo-controlled design, supplemental PS has been associated with a reduced cortisol response to intense exercise stress.(4) This matters for men because chronically elevated stress chemistry can quietly erode performance across the board: motivation and drive can flatten, sleep quality can deteriorate, focus becomes less reliable, and testosterone-supportive physiology may take a hit over time. PS is one of the more direct “stress-buffer” tools men commonly include in a serious nootropic stack.
PS is also increasingly interesting in the sports nutrition world because it sits at the overlap of brain performance and physical performance. Researchers have explored it in athletic contexts not only because stress hormones influence recovery, but because mental composure, confidence, and decision-making are part of training output too.
Read more: Phosphatidylserine (PS)
Bacopa monnieri
Bacopa monnieri is one of the classic “memory herbs,” with a long history in Ayurvedic tradition—where it’s associated with sharpening the mind while supporting memory and learning. It’s not a fast-acting nootropic. Bacopa is better understood as something you take consistently for weeks to support the deeper processes behind cognition—learning, retention, recall, and the ability to stay mentally steady under pressure.
Modern research seems to suppoort this reputation. A meta-analysis of randomized controlled trials found that bacopa extract can improve aspects of cognitive function, with particularly consistent signals in attention-related outcomes.(5) And because attention is the gateway to memory (you can’t store what you don’t properly encode), this is one reason bacopa remains a staple in memory-focused nootropic stacks.
Bacopa is also frequently described as having adaptogenic properties—meaning it’s used to help the body and mind better handle stress. That’s especially relevant for men because stress is one of the most common hidden drivers of foggy thinking and cognitive decline in day-to-day life.
Rhodiola rosea
Rhodiola rosea is one of the most “male-relevant” nootropics because it sits right at the intersection of mental performance and physical performance. Traditionally used in harsh climates and demanding conditions, rhodiola built its reputation helping the body and mind handle stress better—so you can keep performing when pressure rises. It is considered an adaptogen, meaning it’s used to support resilience during physical and mental fatigue, stress, and overload.
From a cognition standpoint, rhodiola is most associated with mental stamina: the ability to stay sharp when you’re tired, stressed, or pushing your limits. A lot of men are looking for the ability to stay confident, decisive, and productive even when life is demanding—long workdays, intense training blocks, reduced sleep, travel, or high-pressure responsibilities. Rhodiola may fit those needs.
Rhodiola helps athletic performance as well. In a randomized crossover trial in resistance-trained athletes, short-term rhodiola supplementation was associated with dose-dependent improvements in resistance exercise performance, and researchers also reported nootropic effects on cognitive function.(6)
Overall, rhodiola may support both the physical side of masculinity (training, output, competitive drive) and the cognitive side (focus, mental stamina, and performance under pressure).
L-Theanine
L-theanine is a tea-derived amino acid known for producing “relaxed alertness”—a calmer mind with clearer, more controlled attention. That is helpful for men because performance isn’t just about intensity; it’s also about composure.
When you’re stressed, overloaded, or running hot, focus gets scattered and decision-making gets sloppy. Taking an L-theanine supplement helps shift the brain toward a steadier state—calm enough to think clearly, alert enough to execute. It may even help with improving sleep quality.
In a clinical report on mental state, L-theanine was associated with increased alpha brain wave activity, which is commonly linked with relaxation without drowsiness.(7) And for men who rely on caffeine to perform, L-theanine is a staple stack ingredient because it’s often used to smooth caffeine’s edge—supporting cleaner focus with fewer jitters, tension, or “wired” side effects.
It's worth noting that L-Theanine is present in some caffeinated pre-workout supplements, offering another benefit for men who pursue athletic excellence. Whether in the office or the gym, L-Theanine + Caffeine is a legendary nootropic stack for promoting a healthy masculine mindset: Cool-headed mental alertness and clarity; mind-body intensity without recklnessness or aggression.
Maritime pine bark extract (Pycnogenol®)
Maritime pine bark extract (especially the patented form, Pycnogenol®) is best known for two things that matter to men: circulation support (including cerebral blood flow) and antioxidant protection. That’s why you’ll sometimes see it in pre-workout formulas—better blood flow can translate into better endurance and pump. But it’s also a promising nootropic for helping the brain perform over time (especially as men age).
Pine bark may have some neuroprotective benefits, too. In a double-blind, placebo-controlled trial in healthy elderly individuals, 150 mg/day of Pycnogenol® for three months was associated with improvements in cognitive measures including spatial working memory, alongside changes in oxidative stress markers.(8) For men thinking long-term, this positions pine bark as a “brain health” ingredient that also has real performance upside—because better circulation and less oxidative wear can support both mental clarity today and resilience later.
It may also have unique “bonus lane” benefits that are relevant to men with families: there’s clinical research in boys with ADHD (attention-deficit hyperactivity disorder). In a randomized, double-blind, placebo-controlled trial, children received Pycnogenol® at about 1 mg/kg/day for four weeks, and researchers reported improvements in ADHD-related behavioral outcomes (including attention-related measures) compared with placebo.(9)
Read more: Maritime Pine Bark Extract
Lion’s Mane Mushroom
Lion’s mane (Hericium erinaceus) is one of the few “functional mushrooms” that has been studied for cognition in older adults, which is why it may appeal to men thinking about protecting long-range brain health. For men in their mid-50s and beyond, the goal often shifts to “How do I keep my mind strong, clear, and reliable as I age?” Lion’s mane helps meet that goal because it’s more about supporting the brain’s resilience and healthy aging than rapid brain-boosting effects.
The strongest human evidence comes from a double-blind, placebo-controlled trial in adults with mild cognitive impairment. In that study, lion’s mane taken for 16 weeks improved cognitive test scores during the supplementation period, and scores declined after discontinuation—suggesting any benefit may depend on continued use.(10)
Lion’s mane is also discussed for its potential mood-support angle, which matters more than many men admit. Mood isn’t just “feelings”—it affects drive, motivation, stress tolerance, and the willingness to stay socially engaged and mentally active as you age.
Read More: Lion's Mane Mushroom
N-Acetyl L-Tyrosine
L-Tyrosine (N-Acetyl L-Tyrosine, Tyrosine) is one of the most “male-coded” nootropics because it’s about performance under pressure—the ability to stay sharp, driven, and decisive when demands are high.
Tyrosine is a building block your brain uses to make key “go” neurotransmitters—especially dopamine and norepinephrine—which are heavily involved in alertness, motivation, focus, and cognitive control. Tyrosine is often positioned as a way to help “refill the tank” so your mental performance stays stronger when you’re pushing hard. That’s also why L-tyrosine shows up not only in brain supplements, but in pre-workouts and athletic formulas.
In a randomized, double-blind, placebo-controlled study, tyrosine supplementation was linked to significant improvements in working memory updating during a cognitively demanding task.(11) That’s exactly the type of cognitive function men often want to protect: the ability to hold information in mind, adapt quickly, and keep decision-making sharp when things get intense.
Did you know? L-Tyrosine’s “men’s nootropic” credibility is also strengthened by how often it’s been studied in military-style stress contexts—conditions involving high cognitive load, fatigue, cold exposure, and the need to perform when comfort is not guaranteed. For men, it’s a classic “high-demand day” tool—big meetings, deadlines, long drives, hard training blocks, or any scenario where you need to stay sharp and aggressive (but controlled) from start to finish.
Read more: N-Acetyl L-Tyrosine
Omega-3 Fatty Acids
Omega-3 fatty acids (especially EPA and DHA) are “general wellness” supplements—but they’re also a smart, male-friendly nootropic combo because they support the foundations that make strong cognition possible: healthy brain structure, neurotransmission, stable mood and long-range brain wellness.
One study suggested the Omega-3 DHA may help with memory in people whose dietary intake levels are low. This 6-month, double-blind, randomized, placebo-controlled trial evaluated 176 healthy adults (18–45) with low dietary DHA. Researchers reported that daily supplementation of 1.16 g DHA improved reaction times for episodic and working-memory tasks versus placebo. Notably, working memory speed improved significantly in men, while episodic memory improvments were more obvious in women.(12)
Omega-3s also offer a bonus for men who train or simply have "life mileage": Soothing comfort for joints and post-exercise recovery support. One controlled study in untrained men found that omega-3 supplementation reduced symptoms of delayed onset muscle soreness after exercise-induced muscle damage (vs. placebo).(13)
Overall, omega-3s are a great multitasker nootropic for men. They support brain and mood foundations while also supporting the physical side of masculinity: training, recovery, joint comfort, and long-term wellness.
Love this product! Easy to swallow capsule with no aftertaste.Sarah A
A Good Men’s Multivitamin
Not every nootropic has to be exotic. For many men, one of the smartest brain moves is simply covering the basics—because essential vitamins and minerals help power the systems that make cognition possible: brain energy production, neurotransmitter function, oxygen delivery, stress response, and healthy sleep.
Here’s the masculine angle: the same micronutrients that support brain performance often support key pillars of male health too—especially testosterone support, virility, training recovery, and overall vitality. If you’re looking for a “high ROI” baseline before stacking specialty nootropics, a quality men’s multivitamin can make everything work better.
Here are a few of the most important “brain + masculinity” micronutrients men commonly prioritize:
- Vitamin D3: Supports overall brain health and mood balance, and it’s also strongly associated with male hormone health—men with low vitamin D often prioritize it as part of foundational testosterone support.
- Zinc: Plays roles in neurotransmitter function and cognitive performance, and it’s also one of the most well-known minerals for supporting healthy testosterone levels—especially in men with low intake.
- Magnesium: Supports calm central nervous system function, sleep quality, and brain energy, while also supporting training recovery and male vitality (including healthy hormone balance).
- Selenium: Supports antioxidant defenses and thyroid function (which strongly influences energy and cognition), and it also supports male reproductive health.
- B Vitamins (B6, folate, B12): Help drive brain energy metabolism and neurotransmitter pathways, support focus and mood, and are also involved in systems linked to healthy hormone function and performance.
If you want a strong male nootropic stack, don’t ignore the foundation. A good men’s multivitamin can help ensure your brain has the raw materials it needs to function at a high level—while supporting your masculine health baseline.
Read more: Best vitamins and minerals for brain health & memory
Best Nootropic Supplement for Men: Mind Lab Pro®
If you want the simplest “do it once and cover the bases” option, Mind Lab Pro® is a strong pick because it combines multiple complementary nootropics in one daily stack. Rather than chasing one effect, it’s designed to support multiple performance pillars men care about: it supports productivity, memory, clarity, sustained attention, focus, stress resilience, and consistent mental stamina.
Mind Lab Pro® Ingredients (per serving): Citicoline (CDP Choline) 250mg, Phosphatidylserine (from sunflower lecithin) 100mg, Bacopa monnieri 150mg (24% bacosides), Organic Lion’s Mane Mushroom 500mg (fruit and mycelium), Maritime Pine Bark Extract 75mg (95% proanthocyanidins), N-Acetyl L-Tyrosine 175mg, L-Theanine 100mg, Rhodiola rosea 50mg (3% rosavins, 1% salidrosides), NutriGenesis® Vitamin B6 2.5mg, Vitamin B9 100mcg, Vitamin B12 7.5mcg.
For men specifically, Mind Lab Pro® works well because it’s “multi-angle”: you get memory ingredients (citicoline, bacopa), stress and calm-focus support (L-theanine, rhodiola, PS), and brain-health-friendly additions (lion’s mane, pine bark, B-vitamins). That's why it is known as the Universal Nootropic for "100% Brain Power".
Mind Lab Pro is Research-Backed
Most nootropic supplements are marketing first and science second. Mind Lab Pro® is unusual because it has been evaluated in multiple human studies for its cognitive support potential:
- Study 1 (mental processing speed): In a double-blind, placebo-controlled trial, 30 days of Mind Lab Pro® was associated with improved measures tied to information processing and reaction-time performance versus placebo—an outcome men often feel as “sharper mental speed.”(14)
- Study 2 (memory): In a double-blind, placebo-controlled trial using a standardized memory battery, 30 days of Mind Lab Pro® improved performance across multiple memory functions versus placebo, including recall-oriented outcomes—highly relevant for men who want short term memory that actually sticks.(15)
- Study 3 (brain network efficiency): In a 60-day randomized, double-blind, placebo-controlled study, Mind Lab Pro® did not improve speed/accuracy on the task versus placebo, but it was associated with EEG network changes consistent with increased coordination between brain regions—positioning it more as a “brain health / efficiency” signal than a short-term performance spike.(16)
Read more about the Mind Lab Pro studies
Best Nootropic-Enhanced Pre-Workout for Men: Performance Lab® Pre Lab Pro®
If you want a pre-workout that feels more like “clean performance” than a stimulant bomb, Pre Lab Pro® is a strong choice. It’s built for men who want power and endurance in the gym, but also care about mental sharpness and composure—smooth energy, better focus, and a stronger training mindset without the crash.
Pre Lab Pro® Ingredients (per serving): Natural Caffeine (from Coffea robusta seeds) 80mg, L-Theanine (from Green Tea) 160mg, L-Tyrosine 400mg, Setria® for Sport [L-Citrulline, L-Glutathione (Setria®)] 2200mg, Red Beet Powder (Beta vulgaris L – root) 1500mg, Himalayan Pink Salt 500mg.
For men, this formula hits a smart overlap: performance support for blood flow and training output (citrulline + beet), plus nootropic-style support for focus and intensity (caffeine + L-theanine + tyrosine). The result is a pre-workout that helps you train hard while staying mentally locked in—and still feeling functional afterward.
Best Omega-3 Supplement for Men: Performance Lab® Omega-3
Omega-3s are one of the best “multitasker” supplements men can take because they support far more than one outcome. They’re foundational for brain and mood support, overall wellness, and the kind of recovery and joint comfort that keeps men training consistently. Performance Lab® Omega-3 stands out by using algae-sourced DHA + EPA—so you get a clean, sustainable omega-3 profile without fishy aftertaste concerns.
Performance Lab® Omega-3 Ingredients (per serving): Algal Oil (from life’s™OMEGA 60) 1800mg, Total Omega-3 Fatty Acids 990mg, DHA (Docosahexaenoic Acid) 540mg, EPA (Eicosapentaenoic Acid) 270mg. Serving Size: 3 NutriGels®.
For men, omega-3s are an easy “daily foundation” choice: they support long-range brain health and mood stability, while also fitting perfectly into an athletic lifestyle—helping keep joints and recovery in a better place so you can stay consistent with training and performance goals.
Best Multivitamin for Men: Performance Lab® NutriGenesis® Multi for Men
If you’re building a men’s nootropic routine, a high-quality multivitamin is the foundation that makes everything else work better. Even the best brain stack can feel underwhelming if your baseline nutrition is off—because vitamins and minerals support brain energy, neurotransmitter production, stress response, and the metabolic systems that influence mood, drive, and focus.
NutriGenesis® Multi for Men is positioned as a premium “nutritional insurance” option for men who want a clean, daily multi that supports whole-body performance—energy, cognitive function, immune resilience, and masculine vitality—without the megadose approach that often creates more noise than benefit.
In a men’s stack, this is the “base layer”: it helps cover essential micronutrients that support mental performance and overall wellness, so your nootropics can do their job on top of a stronger foundation.
Performance Lab® NutriGenesis Multi
The world's most advanced multivitamin formula.
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Summary
The best nootropics men can take aren’t about hype—they’re about performance pillars that matter in real life: focus you can control, memory that holds up, calmer stress chemistry, and the kind of mental stamina that stays reliable as you age.
Ingredients like citicoline, bacopa, rhodiola, phosphatidylserine, L-theanine, lion’s mane, and maritime pine bark each bring something useful to the table—but for most men, the simplest path is a well-built stack that covers multiple angles at once.
Mind Lab Pro® stands out because it combines these complementary nootropics in one daily routine—and it’s supported by multiple human clinical trials—making it one of the most practical “all-in-one” nootropic choices for men who want consistent cognitive power without living on stimulants.
References
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- Nakazaki, E., Hamada, T., Hayashi, K., Goto, T., Imai, S., Hiwatashi, A., & Kitamura, H. (2021). Citicoline and memory function in healthy older adults: A randomized, double-blind, placebo-controlled clinical trial. Journal of Nutrition, 151(8), 2153–2160. Link
- Starks, M. A., Starks, S. L., Kingsley, M., Purpura, M., Jäger, R., & Parker, S. (2008). The effects of phosphatidylserine on endocrine response to moderate intensity exercise. Journal of the International Society of Sports Nutrition, 5, 11. Link
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- Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: A double-blind placebo-controlled clinical trial. Phytotherapy Research, 23(3), 367–372. Link
- Colzato, L. S., Jongkees, B. J., Sellaro, R., & Hommel, B. (2013). Working memory reloaded: Tyrosine repletes updating in the N-back task. Frontiers in Behavioral Neuroscience, 7, 200. Link
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- Tartibian, B., Maleki, B. H., & Abbasi, A. (2009). The effects of ingestion of omega-3 fatty acids on perceived pain and external symptoms of delayed onset muscle soreness in untrained men. Clinical Journal of Sport Medicine, 19(2), 115–121. Link
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
