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What Are Nootropics? Brain-Boosters Defined and Explained

By Dr. Ramon Velazquez Ph.D. | |

Nootropics are brain-boosters: Supplements that enhance brain health and cognitive performance.

Nootropics work in many ways to produce a range of health benefits across memory, focus, attention, motivation, relaxation, mood, alertness, stress resistance and more.

Of course, the brain is complex. When we ask the question "What are nootropics," the answer must be equally complex.

This guide discusses the meaning of nootropics in detail: What they are by definition, what they do, and how you can identify true nootropics with the greatest brain health benefits and cognitive effect.

The Evolving Meaning of Nootropic

What are nootropics? Ask Dr. Corneliu Giurgea, the pioneer of nootropic research and development.

Nootropic, n., adj. -- from the Greek nous ("mind") and trepein ("to bend" or "turn"), literally meaning "mind turning." Pronounced: no-uh-TROH-pic.

A nootropic is a substance that enhances brain cognition. But given the brain's complexity, this descriptor is inadequate.

If you're a beginning your journey into nootropics, then you might also be asking yourself some of these questions:

How do nootropics enhance brain cognition? Are there any safety requirements? There are many other questions to consider when trying to figure out if a supplement meets the true definition of nootropics.

To get the full picture on nootropics, we'll need to start from the beginning, with the original 1960s definition.

Dr. Giurgea's Original Definition of Nootropic

Romanian psychologist and chemist Dr. Corneliu E. Giurgea, the founding father of nootropics, was the first to attempt a descriptive criteria for what qualifies as a nootropic, which includes:

  1. Enhancement of memory and learning
  2. Improved cognition under stress
  3. Protection of brain cells (neuroprotective)
  4. Facilitation of cell-to-cell communication
  5. Backed by human research demonstrating brain bioactivity
  6. Absence of usual pharmacological effects of psychotropic drugs1

By the strictest definition, only a handful of true nootropics exist.

But as science has learned more about the brain and identified more brain-beneficial supplements since the 1960s, the original Dr. Giurgea-inspired nootropic definition has expanded dramatically.

Modern Definition of Nootropics

Now, in 2020, if a supplement helps the brain in any way, it may be considered as a "nootropic."

This amounts to a long list of nootropic supplements over 80, in fact that have been linked to brain health in some way.

As the list of nootropics has grown, so has appreciation for the brain's capacity to enhance and improve all aspects of life in all types of people broadening the scope of brain-boosting nootropics even further.

What Are The Health Benefits of Nootropics?

As a result of the evolving meaning of nootropic and widening nootropic audience, the health benefits associated with brain supplements are also more numerous and expansive than ever before. They include enhancements for:

  • Memory - traditional memory pills have evolved into performance-enhancing nootropics that support working memory, storage, recall, learning, knowledge retention and more.
  • Attention - various aspects of attention, focus and concentration that are enhanced by nootropics can give users an edge in productivity.
  • Learning - students of academia and lifelong learners can benefit from nootropics' various enhancements for cognitive learning processes like memory formation, storage and recall.
  • Mood - nootropics that help with relaxation, confidence, mood balance, motivation, sociability, anxiety, happiness and more can optimize cognitive function and improve life performance.
  • Creativity - Brain wave-tuning nootropics can foster relaxed, free-flowing thinking that is conducive to creative thinking, artistic exploration and quiet contemplation.
  • Physical - Although they are brain supplements, nootropics are now in the sports nutrition canon due to their ability to improve motivation, intensify training, and promote focus in the gym.
  • Stress Resistance - Nootropics have well-documented anti-stress benefits that can improve the performance of everyone from multitasking professionals to competitive athletes.

Learn more about the many Benefits of Nootropics

How Do Nootropics Work?

Nootropics that benefit brain health tend to enhance cognition as well, by boosting brain pathways in ways that support sharp cognition.

Typically, nootropics and stack supplements are designed to target one or more (ideally, all) of the six following brain pathways:

  1. Brain Energy - The brain consumes about 20% of the body's total energy, qualifying as the body's most demanding organ.2 Nootropics may support energy metabolism by enhancing mitochondrial efficiency, delivering raw fuel material, and more.
  2. Brain Chemicals - Neurotransmitters facilitate neuron-to-neuron communication, essentially regulating all cognitive and memory functions. Increasing neurotransmitter production, sharpening receptor sensitivity, inhibiting brain chemical breakdown, etc. contribute to a more fully optimized neurotransmitter status.
  3. Brain Bloodflow - Whether affected by injury or age, impaired cerebral circulation can diminish cerebral function.3 Supporting blood vessel integrity and nitric oxide levels may help increase delivery of oxygen and nutrients to the brain.
  4. Brain Waves - Different brainwave frequencies in order from highest to lowest: gamma, beta, alpha, theta, delta correspond to different mental states. Some nootropics can help raise certain frequencies to stimulate desired cognitive effects.
  5. Brain Protection - Antioxidant reduction in free radical damage. Adaptogenic resistance to stress. Nootropic neuroprotectors may assist the brain's natural defenses against toxic compounds and conditions through several adaptive processes.
  6. Brain Regeneration - Very few compounds may benefit neurogenesis, the process by which the brain grows and develops neuronal tissue with goals of brain cell repair, maintenance, and plasticity. Some nootropics find potential neurogenesis success in supplying raw nutritional building blocks and signaling growth factor synthesis and release.4

Smart, skilled nootropic users have a keen eye for nootropic combinations and stacks that boost these brain biopathways simultaneously and safely.

More on How Nootropics Work

What Are the Different Types of Nootropics?

In the long run, enhanced brain health ultimately results in elevated and sustained mental performance.

Contrary to the mass focus on certain synthetic “smart pills," many of the best nootropic supplements sold today are either all natural or extracted from natural sources, and come in various forms:

Essential Nutrients

Vitally essential to brain health and function, immunity and metabolism, vitamin and minerals encompass a wide range of dietary compounds that, depending on your diet, may require supplementation to achieve healthy levels.

Healthy neurotransmitter status, brain energy and cerebral circulation, for example, rely heavily on nootropic B-Vitamins: B6, B9 and B12.


Many of the most popular nootropic ingredients are botanical, ranging from chewed, brewed, and steeped roots and leaves to herbal extracts standardized to their bioactive constituents e.g., bacosides of Bacopa monnieri.5

The herbal class of nootropics is not limited to botanicals, however; Lion's Mane Mushroom is another brain-booster that is associated with traditional herbalism and classified among the herbal nootropics.


Originally classified by Soviet scientists, adaptogens are a referred sub-category of herbal nootropics that may naturally help bolster the brain and body against the negative effects of stress – be it emotional, physical, chemical, cognitive, etc.

Essentially, adaptogens strengthen the body's adaptive resistance to stress, enhancing focus, clarity, and also emotional stability during stressful conditions.6 Rhodiola Rosea is among the best adaptogen nootropics.


Sourced from fish, sunflower, soy, egg yolks, and animal organs, phospholipids are a particular type of fat that play important structural roles in brain cell growth, genesis, and repair.

As we age, brain phospholipid levels decline, a condition potentially ameliorated by phospholipid supplementation.7 Phosphatidylserine (PS) is the top-ranked phospholipid nootropic.

Choline Sources

Choline is a natural nootropic used by the body to make and use fats. The brain is itself 60% fat. Therefore, Choline is an important nootropic for supporting brain structure; invaluable for brain repair, regeneration and plasticity. It also helps form the brain chemical acetylcholine.

Nootropic choline sources either provide choline, or help to raise brain choline significantly via indirect pathways. Choline nootropics work well with phospholipids, and are associated with enhancements to memory, mood and mental energy.

Citicoline features unique multi-tasking nootropic activity including an ability to efficiently raise brain phosphatidylcholine levels that make it the best nootropic choline source.


Antioxidants help to protect the brain against free radicals: Unstable molecules that smash against brain cells, damage their membranes and accelerate aging. There are many antioxidants that can neutralize free radicals. But not all can naturally cross the blood-brain barrier to reach the brain.

Maritime Pine Bark Extract is an excellent nootropic antioxidant because it can cross the blood-brain barrier, possesses high antioxidant activity, and offers complementary support for brain regeneration.

Amino Acids

Perhaps the most multi-functional resource of nootropics, amino acids include a set of organic compounds that may benefit cognition by alleviating brain burnout (L-tyrosine),8 promoting alpha brainwave concentration (L-theanine), or improving mitochondrial energy output (L-carnitine). Bodybuilders and intermittent fasters also share interest in amino acid nootropics for their metabolic benefits.

N-Acetyl L-Tyrosine and L-Theanine are the best nootropic amino acids, with complementary anti-stress, pro-relaxation, clarity sharpening brain benefits.

Individual Nootropics vs. Nootropic Stacks

Nootropic supplements categorize into standalone ingredients and multi-ingredient stacks, and the latter category subdivides into homemade stacks and pre-made stacks.

Depending on any number of personal, cognitive, or health factors, you may be drawn to any of the main methods of nootropic supplementation.

What Are Individual Nootropic Supplements?

Single ingredient supplements often supplied for specialized purposes e.g., L-Tyrosine for stress relief  or cheaply bought in bulk and in conjunction with other standalone bulk ingredients to craft specially enhanced nootropic stack supplements for each individual person.

What Are Nootropic Stack Supplements?

Stacking is the process of combining diverse nootropics into a formula with the goal of compounding and synergizing individual ingredient bioactivities for greater brain-boosting effects. The two types of stacks are called:

  • Homemade Stacks - The DIY biohacker route to enhanced cognition, often tied to the online forum Reddit, in which efficacy and safety are contingent upon the creator's discretion.
  • Pre-made Stacks - Manufactured multi-ingredient supplements, ideally subjected to safety and quality testing.

Whereas the former type of stack allows nootropic enthusiasts to freely customize a virtually limitless combination of formulas, the latter stack provides a more reliable standard of effects although, the value of these supplements and their "effects" are heavily dependent on the manufacturer's competence and credibility.

What is the Best Nootropic Supplement?

Generally, nootropic stack supplements are the best because they combine effective nootropics to produce superior brain power results.

However, stack supplements' effectiveness depends on their formula design. The best nootropic supplements will heavily leverage smart nootropic stacking strategies including:

  • Synergy - Stacking ingredients that mutually amplify and enhance the results of each other's brain-boosting bioactivities.
  • Multiplication - Targeting the same bioeffect through multiple, diverse biopathways for a greater, comprehensive result.
  • Complementation - Complementing, the effects of one nootropic with another nootropic that rounds out the experience.

By effectively covering a wide range of cognitive pathways through synergy, multiplication, and complementation, nootropic supplements may help people  achieve an optimized brain state that makes you prepared to take on any demanding mental task.

In addition to being formulated and stacked to work, the best nootropic supplement must also stay true to the original nootropic definition by having no side effects and no risks while enhancing the brain's overall health.

Mind Lab Pro® is the very definition of nootropic.

Enhances Many Cognitive Functions

Just as the definition of nootropic specifies, Mind Lab Pro® enhances learning, improves memory and more. In fact, with its innovative Universal Nootropic™ stack strategy, Mind Lab Pro® optimizes the whole brain to enhance all types of thinking and cognitive abilities.

Supports Brain Health in Many Ways

Sharp mental performance and healthy brain function go hand in hand. In addition to boosting brain power, Mind Lab Pro® 's holistic Universal Nootropic™ approach optimizes brain health in many ways to best support long-range mental clarity.

Clean, Safe and Side Effect-Free

All 11 ingredients in Mind Lab Pro® are safe and well-tolerated. But that’s just part of the story. All Mind Lab Pro® ingredients are presented in upgraded, enhanced-potency forms that are easier for the body to absorb and utilize.

Mind Lab Pro®'s innovative formula design and superior quality standards produce a true nootropic supplement that meets and exceeds the nootropic definition originally set forth by Dr. Giurgea.

Mind Lab Pro® meets and exceeds the true definition of nootropic with 11 effective brain-boosters in a safe, clean and premium-quality formula.


Mind Lab Pro® exemplifies everything a true nootropic supplement should be.

When we ask the question, "What are nootropics?" We are really asking, "What's in it for me?" That is why the common answers relate to nootropics' ability to improve and enhance memory, attention, mental processing and other aspects of cognitive performance.

But to really know what nootropics are, we must look deeper to the original definition of nootropics, and its specific criteria for extremely good safety profiles, human research-backed bioactivities, outstanding tolerability, and brain-protective properties.

In other words, a true nootropic can't just boost brain power it must nourish the brain and improve brain health while doing absolutely no harm to the user.

Mind Lab Pro® is the most advanced true nootropic you can buy unleashing 100% Brainpower™ while adhering to the safe, brain-healthy and holistic nootropic philosophies set forth by Dr. Giurgea in the 1960s.


  1. Giurgea C, Salama M. Nootropic drugs. Progress in Neuro-Psychopharmacology. 1977; 1(3-4): 235-247.
  2. Magistretti PJ, Allaman I. A cellular perspective on brain energy metabolism and functional imaging. Neuron. 2015 May 20; 86(4): 883-901.
  3. Miyazaki , M. Correlation between cerebral circulation and intellectual impairment in patients with “Aging Brain”, and the effect of vinpocetine on cerebral circulation. Drug. Dev. Res, 14:199-204 (1988).
  4. Dyer AH, et al. The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity. Neuroscience. 2016 Jun 14;325:89-99.
  5. Kishore K, Singh M. Effect of bacosides, alcoholic extract of Bacopa monniera Linn. (brahmi), on experimental amnesia in mice. Indian J Exp Biol. 2005 Jul;43(7):640-5.
  6. Panossian A, Wagner H. Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. Phytother Res. 2005;19(10):819–38.
  7. Crook TH, et al. Effects of phosphatidylserine in age-associated memory impairment. Neurology. 1991 May;41(5):644-9.
  8. Banderet LE, Lieberman HR. Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain Res Bull. 1989 Apr;22(4):759-62.

These statements have not been approved by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

This article is an opinion and explanation of current research given by the author. It is not an expression of a medical diagnosis or treatment and should not be relied on as such.

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