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Best Lion's Mane Supplement

By Abigail Roberts | |

Want to boost your brain with Lion's Mane? You're in the right place. In this article, we're going to help you find the best Lion's Mane supplement on sale today.

Lion’s mane is a unique mushroom that supports both cognitive performance and overall brain wellness. Plus additional possible benefits for immune function, gut health and more.

But consuming Lion's Mane Mushroom can be tricky. As a culinary mushroom, Lion's Mane may be challenging to find. And there are many lion's mane supplements and stack supplements on the market that vary wildly in price and quality.

The nootropic brain-booster Mind Lab Pro is the top dietary supplement with lion's mane extract in 2022, due to its high quality and ultramodern formula design. It provides 11 nootropics total, including lion's mane -- combining their best benefits to unleash a whole-brain boost.

But before we dig into Mind Lab Pro, let's talk about one of its star nootropic ingredients: Lion's mane powder.

What is Lion’s Mane Mushroom?

Lion’s mane (Hericium erinaceus), also known as Yamabushitake or Hedgehog Mushroom, is a mushroom used in cuisine and traditional Chinese medicine herbalism practices.

It is increasingly recognized as an effective nootropic (brain-boosting) supplement with a wide range of cognitive benefits.

Lion’s mane can be consumed raw, cooked, steeped in tea, or taken as a supplement. It gets its name from the clear resemblance of an actual lion’s mane, due to the long white spines that grow from its body and droop downwards.

A prized medicinal mushroom, lion's mane has been used safely and effectively for centuries in Asian health traditions. Today, modern science is beginning to understand the biological activities behind this unique mushroom's benefits.

How Lion’s Mane Mushroom May Work

As a nootropic, Lion's mane mushroom appears to work by helping to regenerate and protect the brain. The compounds in lion’s mane that drive these bioactivities, called hericenones and erinacines, are extracted using hot water.

Lion’s Mane's hericenones and erinacines have been shown in research to promote nerve growth factor (NGF) synthesis.

Nerve growth factor is suggested to help the brain in many ways, including:

  • Helping the growth and health of brain cells and nerves throughout the body
  • Playing key roles in neurogenesis, which refers to the creation of fresh new neurons
  • Promoting brain plasticity: New neural connections that underlie memory and learning
  • Supporting myelin, the fatty sheathing that surrounds and protects nerves
  • Inadequate nerve growth factor levels have been linked to low mood, cognitive decline and memory issues

The NGF-boosting bioactivity lion’s mane offers is a rare find among supplements. It is highly desirable due to the benefits on brain and nerve health and mental performance.

The best lion's mane mushroom supplements offer foundational support for memory, mood and overall cognition. They are also suggested to help reduce brain fog in cases of mild age-related cognitive decline

Lion's mane is increasingly researched for its ability to nourish the brain. Most studies are animal trials, but some promising human studies have also been carried out. Let's take a closer look at some of the research behind lion's mane.

Lion's mane may Improve mental performance in mild cognitive impairment

In one double-blind, placebo-controlled clinical trial, subjects aged 50-80 took Lion’s Mane Mushroom or placebo three times a day for 16 weeks.

Researchers found that the Lion’s Mane supplementation was associated with enhanced cognitive performance scores, and that cognitive testing scores dropped four weeks after supplementation ceased.

The researchers concluded that Lion’s Mane may be a helpful therapy in cases of mild cognitive impairment.

Lion's mane may be Helpful for Anxiety and Depression

An early study investigated if Lion’s Mane might affect the moods and mind-states of 30 women in the age range of 40, all of whom presented a range of complaints related to menopause, mood, low cognitive performance, poor sleep and others.

Subjects took either a Lion’s Mane mushroom (in powder form) infused cookie or placebo for a duration of four weeks. At the study’s conclusion, researchers reported that Lion’s Mane supplementation may promote emotional balance, especially in the context of blue or worrisome moods.

Lion's mane may Support longer-range brain wellness

Lion’s Mane Mushroom’s NGF activity may indirectly protect the brain by promoting healthy brain structure and nerve myelination.

Some early animal research also suggests that Lion’s Mane mushroom may help to protect the brain against irregular proteins that are associated with brain degeneration.

Potential Immune Benefits

Beyond the brain, Lion's Mane may help support the immune system. It is suggested to boost immune performance by nourishing gut probiotics, which in turn help to fight pathogens and strengthen gut barrier defenses.

Lion’s mane proteins may also hold potential as a therapy for gastric issues that are related to immune system functions.

Protection against digestive ulcers

Taking lion's mane supplements may be beneficial for digestive health. One study has suggested that lion’s mane may reduce the growth of H. pylori, a bacteria that can become problematic when overgrown, potentially causing stomach ulcers.

What should you look for in a Lion's Mane supplement?

We've laid out why the best lion's mane capsules and powder supplements are skyrocketing in popularity.

Real mushrooms are red-hot in the natural health world, and Lion's Mane -- due to its unique brain-boosting activity -- is in especially high demand. As a result, there are a lot of lion's mane mushroom supplement products on the market.

So how can you decide which lion's mane product to buy? Here are some tips that separate the best lion's mane mushroom supplements from the rest of the pack.

Here are 5 features to look for to find a great lion's mane mushroom product:

Fruiting bodies from real mushrooms, not mycelium (mushroom roots).

The fruiting body is the above-ground, stem-and-cap part of the mushroom that produces spores. Mycelium, on the other hand, is the mushroom's root-like lower structure.

Lion's mane extract capsules typically supply active ingredients sourced from the fruiting body and/or mycelium. But which is best to look for when buying a lion's mane mushroom product?

Most mushroom supplements are made of mycelia grown on grains like corn and rice. Lion's mane mycelium is a cheaper source of its active compounds, but it has drawbacks.

First off, mycelia doesn't have the same exact nutritional profile as the fruiting body. This may be important because most research on lion's mane has focused on the fruiting body.

The other concern with mycelia is related to its production. The mushroom "roots" bind with the grain growing medium, becoming impossible to separate. The end product can still be used in supplements, but only if the mycelia and grain medium are pulverized together into a powder.

In these cases, the finished mycelium mushroom product is "diluted" by grain: Not as strong as pure extract, and not suitable for those who are avoiding grains.

Unlike mycelia, mushrooms' fruiting bodies have been consumed for thousands of years, and are extensively researched. They have also been shown to have higher levels of active ingredients than grain-grown mycelia.

When it comes to finding quality organic lion's mane capsules or powders, look for real brain-boosting nutrition from real mushrooms.

In the best lion's mane supplements, pure powder is produced from the fruiting bodies of premium mushrooms. This form may also be listed on real mushrooms supplements labels as "whole fruiting body" or simply "fruit".

Full-spectrum hot water extracts of Lion's mane

The best lion's mane products will present all of the active constituents, mirroring real mushrooms. In traditional herbalism, this is known as a "full spectrum" extract, and is believed to allow the mushroom's beta glucans and other constituents to work together in synergy.

Full spectrum lion's mane products are guaranteed to deliver the mushroom's active beta glucans, including its beneficial nootropics.

Hot water extracted lion's mane is a clean, eco-conscious method of delivering the mushroom's active compounds, and is considered a sign of product quality.

Effective lion's mane dosage in each supplement serving

Doses of lion's mane vary. At the time of writing, there has been no reported optimal dose of lion’s mane mushrooms in supplement form.

However, doses of 500mg appear to be effective. Doses of up to 3000mg per day have been noted, though more is not necessarily better.

Free-flowing Lion's mane powder supplements allow the user to customize dosage. However, they are less convenient than lion's mane capsules.

Clean, high-quality, organic mushrooms sources

You can't assume that all lion's mane supplements are clean label and high quality.

However, by seeking out USDA certified organic lion's mane mushrooms, you can get a little closer to the natural nutritional profile you'd expect from real mushrooms.

Certified organic mushroom supplements will be clearly noted on the label.

Smart "stacking" strategies with other nootropics

A mushroom supplement can supply just lion's mane mushroom powder, and no other ingredients. Standalone lion's mane supplement products are convenient for those seeking higher doses of the mushroom.

However, especially in the context of brain function, the single-ingredient lion's mane supplement may fall short because it misses the advantages of "stacking" the mushroom with other nootropic brain-boosters.

On its own, lion's mane supports some cognitive functions and some aspects of overall brain wellness.

When combined with other nootropics, however, lion's mane has the potential to help with much more.

As such, the most effective way to take lion’s mane is as part of a well-designed "stack" supplement that combines several nootropics into one far-reaching formula.

This brings us to the best nootropic stack supplement with lion's mane you can buy on the market today: Mind Lab Pro.

The Best Nootropic Formula with Lion’s Mane

If you want to take lion's mane to support brain health and mental performance, consider getting this mushroom in the greatest nootropic stack on the market today: Mind Lab Pro.

Mind Lab Pro functions as a whole-brain optimizer. It adapts to meet cognitive performance demands, no matter your needs or task. The clean formula of Mind Lab Pro boosts cognitive health, neurological health and overall brainpower while avoiding all stimulants and additives.

Mind Lab Pro supplies 500mg of USDA Certified Organic Lion's Mane Mushroom with full-spectrum actives that are water-extracted from the fruiting body.

It is also guaranteed to supply Lion’s Mane mushroom beta glucans for brain wellness: Hericenones and erinacines.

But the best lion's mane powder is just one brain boosting nootropic found in Mind Lab Pro capsules.

This innovative formula skillfully stacks 10 additional nootropics on top of lion's mane, helping to optimize a wider array of cognitive functions and brain health benefits.

Beyond the best lion's mane mushroom, nootropic ingredients in Mind Lab Pro include:

  • Vitamin B6, B9, B12 (NutriGenesis)
  • Citicoline
  • Bacopa Monnieri
  • Phosphatidylserine
  • N-Acetyl L-Tyrosine
  • L-Theanine (Suntheanine)
  • Rhodiola Rosea
  • Maritime Pine Bark Extract

As a single-ingredient product, the lion's mane supplement in capsule form can help with memory, mood and overall brain health.

But by including additional nootropics, Mind Lab Pro expands the benefits to include:

  • Focus
  • Attention
  • Mental clarity
  • Stress resistance
  • Cognitive performance under pressure
  • Helping to alleviate brain fog
  • Brain processing speed
  • Virtually any other cognitive function you can imagine

Mind Lab Pro is also carefully designed with nootropics that play well together.

For example, in Mind Lab Pro the best Lion’s Mane powder combines with citicoline and phosphatidylserine to form a 3X brain structure support stack. Each of these nootropics optimizes brain regeneration and repair via a different, yet complementary, brain pathways -- potentially unleashing greater overall benefits.

Another example: Mind Lab Pro Maritime Pine Bark extract promotes brain derived neurotrophic factor (BDNF), which works in concert with lion's mane and its nerve growth factor (NGF) support.

And, unlike many other nootropic stacks and single ingredient lion's mane capsules, Mind Lab Pro supports your mental performance in the short-term and healthy brain function in the long term -- all without using unreliable and crash-inducing stimulant ingredients.

Mind Lab Pro is the best quality lion's mane supplement.

It is worth noting that Mind Lab Pro is also a clean supplement. It is vegan friendly, gluten free, and extensively tested to ensure that each capsule is free of contaminants such as heavy metals. Its Lion's mane is certified organic, water-extracted and guaranteed to supply active beta glucans.

More on how Mind Lab Pro works


Q: Can you put Lion's Mane in coffee?
A: Yes, you can steep the mushroom in hot water to make a tea. You can also find coffee infused with extracts of lion's mane mushroom.

Q: Can you take Lion's Mane before bed?
A: Yes, you can take lion's mane before bed or at any other time during the day. Take before bed for potential natural sleep aid, or in the morning or afternoon to enhance cognitive function throughout the day.

Q: What are the benefits of Lion's Mane?
A: Lion's mane mushroom supplement has been shown to have various health benefits, from protecting against cognitive decline, brain fog, immune boosting, helping repair nerve damage, and reducing mild symptoms of anxiety and depression.

Q: Do Lion's Mane supplements work?
A: Lion's mane supplements that deliver fruiting body extract in capsule form have been tested in clinical human research studies. Some of these studies suggest mushroom extracts may assist with cognitive health and general wellness in many ways, including alleviating brain fog, sharpening mental clarity, helping support brain wellness, offering unique nervous system support, nourishing the immune system and more. Lion's mane benefits are attributed to active compounds called beta glucans.

Q: How long does Lion's mane take to work?
A: Mind Lab Pro suggests that Lion's mane, along with the other nootropics in its formula, should be taken for 30 days before assessing its effects.

Q: What does Lion’s Mane feel like?
A: If you are experiencing age-related brain fog, this mushroom may help to clear it up. It is also associated with a more balanced and healthy mood, especially in women approaching menopause. Early research and anecdotal reports suggest its effects may be noticed as sharper memory and recall, as well as in an enhanced overall mental clarity.

How To Use Lion's Mane

How often should I take Lion's Mane?

It is recommended to take lions mane supplements daily in order to see the best results.

Mind Lab Pro, containing 500mg of organic lion's mane mushroom powder, is to be taken daily, and increasing your dose is recommended in times of intense cognitive demand.

How long does Lion's Mane last?

One study noted that the cognitive-enhancing effects of lion's mane medicinal mushrooms in supplement form reduced four weeks after stopping supplementation.5 This implies that the effects of lion's mane may last anywhere up to 4 weeks.

However, it is recommended to consistently take lion's mane supplements long-term for the best cognitive-enhancing results and future neurological health.

What time of day should I take Lion's Mane?

You can take lion's mane any time during the day. However, the benefits of the entire mushroom aren't unique to our waking life. Some research has suggested you could take lion's mane before bed, as it may act as a sleep aid.

Though, the best lion's mane supplement, Mind Lab Pro, is to be taken during the morning or afternoon so you can reap the cognitive-enhancing effects throughout the day.

Lion's Mane Mushroom Side Effects

Lion’s mane supplements are generally well tolerated. However, they are not recommended for those who have an allergy to mushrooms.

Lion's mane has been suggested to affect the body's blood clotting ability, and has been linked to some instances of indigestion and upset stomach. Those experiencing side effects should stop taking lion's mane immediately.

Mind Lab Pro is a clean nootropic stack containing lion's mane mushrooms, and is known to have no side effects, and is well-tolerated.


Mushrooms are experiencing strong growth in the supplement industry. Now in 2022, products are supplying the active health-promoting beta glucans found in real mushrooms in more convenient forms than ever before. But not all mushroom products are created equal.

Mind Lab Pro is a clean nootropic stack containing lion's mane mushrooms as a full extract, with all its beta-glucans intact. If you are looking to get the health-enhancing power of real mushrooms, including lion's mane, on a day-to-day basis, consider a stack supplement like Mind Lab Pro.

These statements have not been approved by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

This article is an opinion and explanation of current research given by the author. It is not an expression of a medical diagnosis or treatment and should not be relied on as such.

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