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Best Lion's Mane Supplement

By Abigail Roberts | |

You will have likely heard of nootropics before, particularly for enhancing memory, motivation, mood, and focus to thus optimize your mind.

They're a great supplement pick for students and working professionals alike, whether you’re seeking to boost your cognitive function in the short or long term.

Lion's mane supplements are some of the most popular nootropics on the market right now. The best Lion's mane supplements offer the same benefits as top nootropic stacks, with few side effect risks.

Lion’s mane is a unique edible mushroom, offering some of the best neuroprotective and nootropic effects by enhancing cognitive function and improving memory.

But finding the right Lion's Mane Mushroom supplement for you can be tricky.

As this mushroom species becomes increasingly popular, the number of Lion's Mane supplement stacks on sale increases too.

However, most of these supplements are substandard, offering few benefits for wildly inflated price tags.

In this article, we're going to help you find the best Lion's Mane supplement on sale today.

We will explain how to find the most effective Lion's Mane supplement, what Lion's Mane does, and how it works. But first, let's take a look at the top Lion's Mane Mushroom supplement on the market right now.

Top Lion's Mane Supplement: Mind Lab Pro

Lion’s mane extract is one of the main ingredients in Mind Lab Pro, one of the best, most potent nootropics today.

Mind Lab Pro functions as a whole-brain optimizer, helping you to perform better mentally. It adapts to meet mental performance demands, no matter your needs or task, while avoiding all stimulants and additives.

The clean formula of Mind Lab Pro boosts cognitive health, neurological health, and mental function. Mind Lab Pro contains 500mg of lion's mane mushroom extract, which clinical trials show is an optimal daily dose of the medicinal mushroom to enhance long-term cognitive performance and brain health.

Now let's take a closer look at the benefits of lion’s mane mushroom and why it is one of the most effective ingredients in Mind Lab Pro.

What is Lion’s Mane Mushroom?

Lion’s mane (Hericium Erinaceus), also known as Yamabushitake, or Hedgehog Mushroom, is an ancient Chinese medicinal mushroom that is now becoming recognized as an effective supplement that offers a wide range of cognitive benefits.

Lion’s mane can be consumed raw, cooked, steeped in tea, or taken as a supplement. It gets its name from the clear resemblance of an actual lion’s mane because of the long white spines that grow from the main body and droop downwards.

Lion’s mane was used for centuries as a health treatment for neurodegenerative diseases, and rightly so, as it has proven neuroprotective qualities.

Research has also confirmed it has potential anti-depressant and anxiolytic properties, making it a sought-after nootropic for enhancing cognitive function, as well as improving mood.

This is why Lion's mane supplements are becoming so popular; they provide wide-ranging beneficial effects from nerve health, neurological health, immune-boosting effects, and potentially even digestive health.

Let’s take a deeper look into the benefits of lion’s mane supplements!

The Health Benefits of Lion’s Mane Mushroom

A variety of health benefits of lion’s mane supplements have been noted from animal-based research and small clinical trials, though it appears very promising at the time of writing!

Here are some of the main benefits of Lion's Mane supplements noted so far:

Enhanced memory and brain health

Some studies suggest lion’s mane to be a real potential cognitive enhancer.1

It’s been shown to reduce cognitive decline in older individuals, and some findings could even possibly support the concept of lion’s mane being of benefit to those who have Alzheimer’s disease and other neurological disorders.

Many of these cognitive enhancing benefits result from the active nootropic in lion’s mane, called hericenones and erinacines. These compounds help stimulate the synthesis of nerve growth factor (NGF), promoting overall brain health and function. More on this later!

Anti-inflammatory and antioxidant activity

Early studies have noted the potential anti-inflammatory effects and antioxidant properties of lion’s mane mushroom. These properties may help reduce the impact of chronic illnesses such as autoimmune disorders, heart disease, and some cancers, as the root cause of these conditions is believed to be chronic inflammation.1

Protection against digestive ulcers

Lion's mane supplements may be beneficial for digestive health. One study has suggested that lion’s mane may reduce the growth of H. pylori, a bacteria that can become problematic when overgrown, potentially causing stomach ulcers.2

Anti-depressant and anxiolytic properties

Lion’s mane has been shown to potentially improve symptoms of depression and anxiety.

In one study, subjects were fed cookies containing lion’s mane, upon which significant improvements in anxiety, concentration, and irritation were noted. Sleep quality also improved as a result, though more research needs to be done in this area to confirm.1

Reduction in menopausal symptoms

In one study, menopausal women noted a reduction in feelings of anxiety and irritation after consuming extracts of lion’s mane daily for one month. These symptoms were associated with menopause, implying that lion’s mane may aid those going through menopause.1

How Does Lion’s Mane Work?

Lion’s mane is known to be the best nootropic for Nerve Growth Factor (NGF) - a type of protein that regulates growth, development, and maintenance of sympathetic and embryonic sensory neurons and assists in the survival of nerve cells.3

Healthy NGF levels are known to support plasticity, brain regeneration, nerve health, and much more. Inadequate levels of NGF have been linked to low mood, cognitive decline, and memory issues.4

As a result of stimulating NGF production, lion's mane supplements may support increased brain storage of new learning and memories, as well as promote healthy brain cell membrane function and reducing cognitive decline over time. These effects will significantly enhance cognitive function, improving your memory and clarity, and make you feel focused and sharp.

The NGF-boosting bioactivity lion’s mane offers is a rare find among supplements but is highly desirable due to the benefits on brain and nerve health, mental performance, and protective effects.

To sum up, research suggests that lion’s mane supplements can boost brain function through supporting NGF levels, thus increasing cognitive function and potentially improving mood and easing symptoms of anxiety.

How To Use Lion's Mane

How often should I take Lion's Mane?

It is recommended to take lions mane supplements daily in order to see the best results.

Mind Lab Pro, containing 500mg of lion's mane mushroom extract, is to be taken daily, and increasing your dose is recommended in times of intense cognitive demand.

How long does Lion's Mane last?

One study noted that the cognitive-enhancing effects of a lion's mane mushroom supplement reduced four weeks after stopping supplementation.5 This implies that the effects of lion's mane may last anywhere up to 4 weeks.

However, it is recommended to consistently take lion's mane supplements long-term for the best cognitive-enhancing results and future neurological health.

What time of day should I take Lion's Mane?

You can take lion's mane any time during the day. However, the benefits of this medicinal mushroom aren't unique to our waking life. Some research has suggested you could take lion's mane before bed, as it may act as a sleep aid.

Though, the best lion's mane supplement, Mind Lab Pro, is to be taken during the morning or afternoon so you can reap the cognitive-enhancing effects throughout the day.

Lion’s Mane Mushroom Dosage

Doses of lion's mane vary, though, at the time of writing, there has been no reported optimal dose of lion’s mane supplements.

However, doses of 500mg appear to be very effective. Doses of up to 3000mg per day have been noted, though more is not necessarily better, and these high doses do not offer any additional benefits.

High doses of lion's mane are not shown to be more effective than doses of 500mg and may even increase the risk of adverse effects.

Mind Lab Pro contains 500mg of lion's mane extract and is a proven effective dose with no reported side effects.

Lion's Mane Mushroom Side Effects

There have been no noted side effects of taking lion’s mane supplements, though it is not recommended for those who have an allergy to mushrooms.

Mind Lab Pro is a clean nootropic stack containing extracts of lion's mane, and is known to have no side effects, and is well-tolerated.

The most effective way to take lion’s mane is as part of a nootropic formula - let’s delve a bit deeper into this!

What to Look for in a Nootropic Supplement

Nootropics are substances known to help memory, attention, learning, or any other aspect of cognition. Simply put, nootropics are brain-boosters!

While individual ingredients in a nootropic formula are recognized for the positive effects on the brain, stacking these ingredients can really help unlock the brain’s full potential by optimizing several pathways.

Combining nootropics can maximize overall brain function by working synergistically to enhance various brain activities for greater results.

The Best Nootropic Formula with Lion’s Mane

Introducing Mind Lab Pro, an innovative formula stacking 11 different nootropics into one, helping to optimize a wide array of cognitive functions to boost brainpower.

Lion’s mane is one of the key ingredients in the Mind Lab Pro formula, alongside:

  • Vitamin B6, B9, B12 (NutriGenesis)
  • Citicoline (Cognizin)
  • Bacopa Monnieri
  • Phosphatidylserine
  • N-Acetyl L-Tyrosine
  • L-Theanine
  • Rhodiola Rosea
  • Maritime Pine Bark Extract

The lion’s mane in Mind Lab Pro is the full spectrum extract, supplying all the mushroom's constituents and nootropic actives hericenones and erinacines.

Unlike many other nootropic stacks, Mind Lab Pro supports your mental performance in the short-term and healthy brain function in the long term.

Final thoughts: What is the best Lion's Mane supplement you can buy today?

Lion's mane mushroom is one of the best nootropics for memory and focus on the market today.

It's no wonder with its ability to boost cognitive function, reduce symptoms of anxiety and depression, improve immunity, and protect against cognitive decline and nerve damage.

There are many lion's mane supplements available today, though taking it as an isolated supplement for boosting brainpower may not be as effective as taking it as part of a nootropic stack.

This is why the best lion's mane supplement you can buy today is Mind Lab Pro!

Mind Lab Pro is not just a Lion's Mane Mushroom supplement, but a complete daily nootropic, boosting your brain power in the short-term and nourishing and protecting the brain for long-term healthy function.

Mind Lab Pro is the world's first Universal Nootropic, boosting all aspects of cognition in all types of people, especially those whose active lifestyles demand dynamic brain power, such as students, working professionals, and athletes.


Q: Does Lion's Mane help ADHD?
A: It is speculated that lion's mane supplements may help ease symptoms of ADHD in children. As lion's mane helps synthesize Nerve Growth Factor (NGF), higher NGF results in more neurons being formed. More neurons mean more brain processing power, directly correlating to an increase in memory, learning, and concentration. This may benefit those who live with ADHD.

Q: Can you put Lion's Mane in coffee?
A: Yes, you can steep lion's mane mushroom in hot water to make a tea, and can also find coffee infused with extracts of lion's mane mushroom.

Q: Can you take Lion's Mane before bed?
A: Yes, you can take lion's mane before bed or at any other time during the day. Take before bed for potential natural sleep aid, or in the morning or afternoon to enhance cognitive function throughout the day.

Q: What are the benefits of Lion's Mane?
A: Lion's mane mushroom has been shown to have various health benefits, from protecting against cognitive decline, anti-inflammatory, immune boosting, helping repair nerve damage, and reducing mild symptoms of anxiety and depression.


  1. K. Patel. Lion’s Mane. Examine.com. 2021
  2. Jiang S, Wang S, Sun Y, Zhang Q. Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals. Appl Microbiol Biotechnol. 2014 Sep;98(18):7661-76
  3. Tanaka A, Matsuda H. Expression of nerve growth factor in itchy skins of atopic NC/NgaTnd mice. J Vet Med Sci. 2005 Sep;67(9):915-9.
  4. Aloe, L., Rocco, M.L., Bianchi, P. et al. Nerve growth factor: from the early discoveries to the potential clinical use. J Transl Med 10, 239 (2012).
  5. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009 Mar;23(3):367-72.

These statements have not been approved by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

This article is an opinion and explanation of current research given by the author. It is not an expression of a medical diagnosis or treatment and should not be relied on as such.

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Mind Lab Pro® is the world's first Universal Nootropic™ – formulated to promote a healthy, peak-performing mindstate known as 100% Brainpower™.

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